Evidence map›Paper›PMID 32359436›Full record

ReviewCell2020

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.

Barry Honig, Lawrence Shapiro

Abstract readReview
In one paragraph

Review in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

  1. Visualization of membrane-stabilized SorCS2Journal of structural biology: X · 2026
    Article
  2. Review
  3. Article
  4. eLife · 2026
    Article
  5. Article
  6. Article
  7. Membrane-Associated Biomolecules for Synthetic Cell Signalling.Chembiochem : a European journal of chemical biology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Calcium Phosphate Nanoparticle Delivery of siInternational journal of nanomedicine · 2026
    Article
  19. On the same side: VISTA and its ligands interact in cis on the cell surface.Protein science : a publication of the Protein Society · 2026
    Article
  20. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barry HonigZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA; Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA. Electronic address: bh6@columbia.edu.
Lawrence ShapiroZuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: lss8@columbia.edu.

Funding

Integrative Structural and Functional Characterization of Tip-Link Cadherins DeafnessR01DC016960 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MUELLER, ULRICH, SHAPIRO, LAWRENCE S · 2018 to 2022
$3.3M
The structural basis of cis and trans protocadherin interactionsR01MH114817 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2017 to 2021
$2.4M
Structure and mechanism of pemphigus autoantibodiesR01AR073846 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRO, LAWRENCE S · 2018 to 2022
$2.4M
Structure and Function of Desmosomal CadherinsR01GM118584 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRO, LAWRENCE S · 2017 to 2020
$1.8M
NIAMS NIH HHS R01 AR073846NIDCD NIH HHS R01 DC016960NIGMS NIH HHS R01 GM118584NIMH NIH HHS R01 MH114817
6 · The paper itself

Abstract

The ability of cells to organize into multicellular structures in precise patterns requires that they "recognize" one another with high specificity. We discuss recent progress in understanding the molecular basis of cell-cell recognition, including unique phenomena associated with neuronal interactions. We describe structures of select adhesion receptor complexes and their assembly into larger intercellular junction structures and discuss emerging principles that relate cell-cell organization to the binding specificities and energetics of adhesion receptors. Armed with these insights, advances in protein design and gene editing should pave the way for breakthroughs toward understanding the molecular basis of cell patterning in vivo.

Indexed as

AnimalsBody PatterningCell AdhesionCell CommunicationHumansMolecular StructureProteinsProteins

Identifiers

PMID32359436
PMCPMC7233459

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.