ArticleNeuron2020
The Dentate Gyrus Classifies Cortical Representations of Learned Stimuli.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Dynamics of Dentate Gyrus Place Cells and Dentate Spikes during Spatial and Nonspatial Changes in Environments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
- Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input.Nature communications · 2026Article
- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- Dentate Gyrus activation during visual but not auditory pattern separation: an investigation of perceptual modality differences in young and old individuals using fMRI.Frontiers in psychiatry · 2026Article
- Hippocampal sequences represent working memory and implicit timing.Cell reports · 2025Article
- Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Dentate gyrus norepinephrine ramping facilitates aversive contextual processing.Nature communications · 2025Article
- Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Review
- An open-source behavior controller for associative learning and memory (B-CALM).Behavior research methods · 2024Article
- Termination of convulsion seizures by destabilizing and perturbing seizure memory engrams.Science advances · 2024Article
- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.Advances in neurobiology · 2024Review
- Odors in space.Frontiers in neural circuits · 2024Review
- Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus.Neuron · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus granule cells (DG GCs) and lateral entorhinal cortex (LEC) neurons across days to understand how sensory representations are modified by experience. We found representations of odors in DG GCs that required synaptic input from the LEC. Odor classification accuracy in DG GCs correlated with future behavioral discrimination. In associative learning, DG GCs, more so than LEC neurons, changed their responses to odor stimuli, increasing the distance in neural representations between stimuli, responding more to the conditioned and less to the unconditioned odorant. Thus, with learning, DG GCs amplify the decodability of cortical representations of important stimuli, which may facilitate information storage to guide behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.