Evidence map›Paper›PMID 32359363›Full record

ArticleBMC anesthesiology2020

Validation of RESP and PRESERVE score for ARDS patients with pumpless extracorporeal lung assist (pECLA).

Jan Petran, Thorsten Muelly, Rolf Dembinski, Niklas Steuer, Jutta Arens, Gernot Marx, Ruedger Kopp

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Effects of extracorporeal COCritical care (London, England) · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jan PetranDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany.
Thorsten MuellyDepartment of Anaesthesiology and Intensive Care Medicine, St. Antonius Hospital, Dechant-Deckers-Straße 8, 52249, Eschweiler, Germany.
Rolf DembinskiClinic for Intensive Care and Emergency Medicine, Bremen-Mitte Hospital, Sankt-Jürgen-Straße 1, 28205, Bremen, Germany.
Niklas SteuerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Pauwelsstr 20, 52074, Aachen, Germany.
Jutta ArensDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty, RWTH Aachen University, Pauwelsstr 20, 52074, Aachen, Germany.
Gernot MarxDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany.
Ruedger KoppDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany. rkopp@ukaachen.de.

Funding

Deutsche Forschungsgemeinschaft 346973239/ SPP 2014
6 · The paper itself

Abstract

backgroundRESP score and PRESERVE score have been validated for veno-venous Extracorporeal Membrane Oxygenation in severe ARDS to assume individual mortality risk. ARDS patients with low-flow Extracorporeal Carbon Dioxide Removal, especially pumpless Extracorporeal Lung Assist, have also a high mortality rate, but there are no validated specific or general outcome scores. This retrospective study tested whether these established specific risk scores can be validated for pumpless Extracorporeal Lung Assist in ARDS patients in comparison to a general organ dysfunction score, the SOFA score.

methodsIn a retrospective single center cohort study we calculated and evaluated RESP, PRESERVE, and SOFA score for 73 ARDS patients with pumpless Extracorporeal Lung Assist treated between 2002 and 2016 using the XENIOS iLA Membrane Ventilator. Six patients had a mild, 40 a moderate and 27 a severe ARDS according to the Berlin criteria. Demographic data and hospital mortality as well as ventilator settings, hemodynamic parameters, and blood gas measurement before and during extracorporeal therapy were recorded.

resultsPumpless Extracorporeal Lung Assist of mechanical ventilated ARDS patients resulted in an optimized lung protective ventilation, significant reduction of P

conclusionsRESP and PRESERVE scores were superior to SOFA, as non-specific critical care score. Although scores were developed for veno-venous ECMO, we could validate RESP and PRESERVE score for pumpless Extracorporeal Lung Assist. In conclusion, RESP and PRESERVE score are suitable to estimate mortality risk of ARDS patients with an arterio-venous pumpless Extracorporeal Carbon Dioxide Removal.

Indexed as

Extracorporeal Membrane OxygenationAdultAgedFemaleHumansMaleMiddle AgedOrgan Dysfunction ScoresRespiration, ArtificialRespiratory Distress SyndromeRetrospective StudiesAcute respiratory distress syndromeExtracorporeal carbon dioxide removalExtracorporeal membrane oxygenationPRESERVE scorePumpless extracorporeal lung assistRESP scoreSOFA score

Identifiers

PMID32359363
PMCPMC7195797

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