ArticleJournal of behavioral addictions2020
Decreased effective connection from the parahippocampal gyrus to the prefrontal cortex in Internet gaming disorder: A MVPA and spDCM study.
Article in Journal of behavioral addictions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- The effect and neural changes underlying mindfulness meditation training in patients with comorbid internet gaming disorder and depression: A randomized clinical trial.Translational psychiatry · 2026Trial
- Radiomics-based feature exploration and auxiliary diagnostic model construction for gaming disorder.Scientific reports · 2026Article
- Connectome-based predictive modelling of problematic gaming in youth from the ABCD study.Journal of behavioral addictions · 2026Article
- Sex Difference in Brain Responses During Short Abstinence in People With Internet Gaming Disorder.Addiction biology · 2026Article
- Mindfulness meditation reduces symptoms and modulates neural circuitry in comorbid internet gaming disorder and depression.PNAS nexus · 2025Article
- Functional connectivity-related changes underlying mindfulness meditation for internet gaming disorder: a randomized clinical trial.Npj mental health research · 2025Article
- Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies.Scientific reports · 2025Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- Article
- Sex differences of neural connectivity in internet gaming disorder and its association with sleep quality: an exploratory fMRI study.Frontiers in psychiatry · 2024Article
- Association between gaming disorder and regional homogeneity in highly involved male adult gamers: A pilot resting-state fMRI study.Brain and behavior · 2023Article
- Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial.Frontiers in psychiatry · 2023Article
- Adverse childhood experiences, problematic internet use, and health-related quality of life in Chinese adolescents.European journal of psychotraumatology · 2023Article
- Altered Brain Structural Reorganization and Hierarchical Integrated Processing in Obesity.Frontiers in neuroscience · 2022Article
- Random Network and Non-rich-club Organization Tendency in Children With Non-syndromic Cleft Lip and Palate After Articulation Rehabilitation: A Diffusion Study.Frontiers in neurology · 2022Article
- Identifying Internet Addiction and Evaluating the Efficacy of Treatment Based on Functional Connectivity Density: A Machine Learning Study.Frontiers in neuroscience · 2021Article
- More stringent criteria are needed for diagnosing internet gaming disorder: Evidence from regional brain features and whole-brain functional connectivity multivariate pattern analyses.Journal of behavioral addictions · 2020Article
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5 authors.
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Abstract
objectivesUnderstanding the neural mechanisms underlying Internet gaming disorder (IGD) is essential for the condition's diagnosis and treatment. Nevertheless, the pathological mechanisms of IGD remain elusive at present. Hence, we employed multi-voxel pattern analysis (MVPA) and spectral dynamic causal modeling (spDCM) to explore this issue.
methodsResting-state fMRI data were collected from 103 IGD subjects (male = 57) and 99 well-matched recreational game users (RGUs, male = 51). Regional homogeneity was calculated as the feature for MVPA based on the support vector machine (SVM) with leave-one- out cross-validation. Mean time series data extracted from the brain regions in accordance with the MVPA results were used for further spDCM analysis.
resultsResults display a high accuracy of 82.67% (sensitivity of 83.50% and specificity of 81.82%) in the classification of the two groups. The most discriminative brain regions that contributed to the classification were the bilateral parahippocampal gyrus (PG), right anterior cingulate cortex (ACC), and middle frontal gyrus (MFG). Significant correlations were found between addiction severity (IAT and DSM scores) and the ReHo values of the brain regions that contributed to the classification. Moreover, the results of spDCM showed that compared with RGU, IGD showed decreased effective connectivity from the left PG to the right MFG and from the right PG to the ACC and decreased self-connection in the right PG.
conclusionsThese results show that the weakening of the PG and its connection with the prefrontal cortex, including the ACC and MFG, may be an underlying mechanism of IGD.
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