SynthesisThe American journal of clinical nutrition2020
Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
Synthesis in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Association of vitamin K intake with physical function, handgrip strength, and mortality among U.S. adults: NHANES 2003-2016.Nutrition research and practice · 2026Article
- Associations among Dietary Intakes, Blood Biomarkers, and Postmortem Brain Tissue Concentrations of Vitamins D and K in Older Adults.The Journal of nutrition · 2026Article
- Prevalence of Vitamin K2 Deficiency and Its Association with Coronary Artery Disease: A Case-Control Study.Diseases (Basel, Switzerland) · 2025Article
- The associations between functional vitamin K status and all-cause mortality, cardiovascular disease and end-stage kidney disease in persons with type 1 diabetes.Diabetes, obesity & metabolism · 2025Article
- An analysis of vitamin K status in Chinese healthy children aged 0-18 years.BMC pediatrics · 2024Article
- Vitamin K: Infection, Inflammation, and Auto-Immunity.Journal of inflammation research · 2024Review
- Six months of different exercise type in sedentary primary schoolchildren: impact on physical fitness and saliva microbiota composition.Frontiers in nutrition · 2024Article
- Vitamin K and Calcium Chelation in Vascular Health.Biomedicines · 2023Review
- Co-supplementation of Vitamin K2 and Selenium Synergistically Improves Metabolic Status and Reduces Cardiovascular Risk Markers in Dyslipidemic Rabbits.Biological trace element research · 2023Article
- Review
- The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence.Frontiers in cardiovascular medicine · 2023Article
- Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort.The American journal of clinical nutrition · 2022Article
- Role of circulating molecules in age-related cardiovascular and metabolic disorders.Inflammation and regeneration · 2022Review
- Association between vitamin KEuropean journal of epidemiology · 2021Article
- Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.Journal of the American Heart Association · 2021Observational
- Perspective: Evidence before Enthusiasm-A Critical Review of the Potential Cardiovascular Benefits of Vitamin K.Advances in nutrition (Bethesda, Md.) · 2021Review
- The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study.PloS one · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundVitamin K-dependent proteins in vascular tissue affect vascular stiffness and calcification, which is associated with cardiovascular disease (CVD) and all-cause mortality.
objectiveTo determine the association of circulating vitamin K concentrations with CVD and all-cause mortality by conducting a participant-level meta-analysis.
methodsWe obtained individual participant-level data from the Health, Aging, and Body Composition Study, the Multi-Ethnic Study of Atherosclerosis, and the Framingham Offspring Study, known cohorts with available measures of fasting circulating phylloquinone (vitamin K-1) and confirmed CVD events and mortality. Circulating phylloquinone was measured in a central laboratory from fasting blood samples and categorized as ≤0.5 nmol/L, >0.5-1.0 nmol/L, and >1.0 nmol/L. Multivariable Cox proportional hazard regression with multiple imputations was used to evaluate the association of circulating phylloquinone with incident CVD and all-cause mortality risk.
resultsAmong 3891 participants (mean age 65 ± 11 y; 55% women; 35% nonwhite), there were 858 incident CVD events and 1209 deaths over a median of 13.0 y. The risk of CVD did not significantly differ according to circulating phylloquinone [fully adjusted HR (95% CI) relative to >1.0 nmol/L: ≤0.5 nmol/L, 1.12 (0.94, 1.33); >0.5-1.0 nmol/L, 1.02 (0.86, 1.20)]. Participants with ≤0.5 nmol/L circulating phylloquinone had an adjusted 19% higher risk of all-cause mortality compared with those with >1.0 nmol/L [fully adjusted HR (95% CI): 1.19 (1.03, 1.38)]. Mortality risk was similar in participants with >0.5-1.0 nmol/L compared with >1.0 nmol/L [fully adjusted HR (95% CI): 1.04 (0.92, 1.17)].
conclusionsLow circulating phylloquinone concentrations were associated with an increased risk of all-cause mortality, but not of CVD. Additional studies are needed to clarify the mechanism underlying this association and evaluate the impact of increased phylloquinone intake on cardiovascular and other health outcomes in individuals with low vitamin K status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.