ReviewJournal of biomedical optics2020
Rise of Raman spectroscopy in neurosurgery: a review.
Review in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Pooled it
- Non-Invasively Quantitative Raman Imaging for Calculation of Lymphatic Transport Kinetics of Micelles in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shining a light on brain tumors: a review of Raman spectroscopy in the operating room.Journal of biomedical optics · 2026Review
- The protocol for mesoscopic wide-field optical imaging in mice: from zero to hero.Biology methods & protocols · 2026Review
- Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025Review
- Envisioning the Future of the Neurosurgical Operating Room with the Concept of the Medical Metaverse.Journal of Korean Neurosurgical Society · 2025Article
- The application of vibrational spectroscopy in forensic analysis of biological evidence.Forensic science, medicine, and pathology · 2025Review
- Preliminary study demonstrating cancer cells detection at the margins of whole glioblastoma specimens with Raman spectroscopy imaging.Scientific reports · 2025Article
- Review
- Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain.Nature methods · 2025Article
- Enhanced spectral resolution and reduced acquisition time in fiber-based wavelength-swept source Raman spectroscopy.Neurophotonics · 2025Article
- Artificial Intelligence-Assisted Stimulated Raman Histology: New Frontiers in Vibrational Tissue Imaging.Cancers · 2024Review
- Current Applications of Raman Spectroscopy in Intraoperative Neurosurgery.Biomedicines · 2024Review
- Review
- Optical Methods for Brain Tumor Detection: A Systematic Review.Journal of clinical medicine · 2024Review
- Vibrational spectroscopy and multiphoton microscopy for label-free visualization of nervous system degeneration and regeneration.Biophysical reviews · 2024Review
- Early Detection of Oral Potentially Malignant Disorders: A Review on Prospective Screening Methods with Regard to Global Challenges.Journal of maxillofacial and oral surgery · 2024Review
- Applications of Raman spectroscopy in the diagnosis and monitoring of neurodegenerative diseases.Frontiers in neuroscience · 2024Review
- Revolutionizing Neurosurgery with GPT-4: A Leap Forward or Ethical Conundrum?Annals of biomedical engineering · 2023Article
- Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model.Journal of biomedical optics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
significanceAlthough the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a revolutionary tool for neurosurgeons.
aimWe give a summary of neurosurgical workflows and key translational milestones of RS in clinical use and provide the optics and data science background required to implement such devices. APPROACH: We performed an extensive review of the literature, with a specific emphasis on research that aims to build Raman systems suited for a neurosurgical setting.
resultsThe main translatable interest in Raman sensing rests in its capacity to yield label-free molecular information from tissue intraoperatively. Systems that have proven usable in the clinical setting are ergonomic, have a short integration time, and can acquire high-quality signal even in suboptimal conditions. Moreover, because of the complex microenvironment of brain tissue, data analysis is now recognized as a critical step in achieving high performance Raman-based sensing.
conclusionsThe next generation of Raman-based devices are making their way into operating rooms and their clinical translation requires close collaboration between physicians, engineers, and data scientists.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.