Evidence map›Paper›PMID 32358816›Full record

Trial reportTransfusion2020

Additive effects of blood donor smoking and gamma irradiation on outcome measures of red blood cell transfusion.

Robert A DeSimone, Colleen Plimier, Catherine Lee, Tamir Kanias, Melissa M Cushing, Bruce S Sachais, Steven Kleinman, Michael P Busch, Nareg H Roubinian

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. It's in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Deformability of Stored Red Blood Cells.Frontiers in physiology · 2021
    Review
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Robert A DeSimoneWeill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-3484-790X
Colleen PlimierKaiser Permanente Northern California Division of Research, Oakland, California, USA.
Catherine LeeKaiser Permanente Northern California Division of Research, Oakland, California, USA.
Tamir KaniasVitalant Research Institute, Denver, Colorado, USA.ORCID 0000-0001-6558-0913
Melissa M CushingWeill Cornell Medicine, New York, New York, USA.ORCID 0000-0001-8042-1494
Bruce S SachaisNew York Blood Center, New York, New York, USA.
Steven KleinmanUniversity of British Columbia, Vancouver, Canada.
Michael P BuschVitalant Research Institute, San Francisco, California, USA.
Nareg H RoubinianKaiser Permanente Northern California Division of Research, Oakland, California, USA.ORCID 0000-0002-1063-6155
Kaiser Permanente · USCornell University · USNew York Blood Center · USUniversity of British Columbia · CAUniversity of California, San Francisco · USVitalant · US

Funding

Effects of blood conservation and donor characteristics on transfused patient outcomes in a large community hospital networkR01HL126130 · NHLBI · VITALANT · PI ROUBINIAN, NAREG · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL126130NHLBI NIH HHS R01HL126130
6 · The paper itself

Abstract

backgroundRecent publications have reported conflicting results regarding the role of blood donor tobacco use on hemoglobin (Hb) levels in patients after red blood cell (RBC) transfusion. We examined associations and interactions between donor, component, and recipient factors to better understand the impact of donor smoking on transfusion outcomes. STUDY DESIGN AND

methodsWe linked blood donor and component manufacturing data, including self-reported cigarette smoking, with a cohort of patients transfused RBCs between 2013 and 2016. Using multivariable regression, we examined Hb increments and subsequent transfusion requirements after single-unit RBC transfusion episodes, adjusting for donor, component, and recipient factors.

resultsWe linked data on 4038 transfusion recipients who received one or more single-unit RBC transfusions (n = 5086 units) to donor demographic and component manufacturing characteristics. Among RBC units from smokers (n = 326), Hb increments were reduced after transfusion of gamma-irradiated units (0.76 g/dL; p = 0.033) but not unirradiated units (1.04 g/dL; p = 0.54) compared to those from nonsmokers (1.01 g/dL; n = 4760). In parallel with changes in Hb levels, donor smoking was associated with the receipt of additional RBC transfusions for irradiated (odds ratio [OR], 2.49; p = 0.01) but not unirradiated RBC units (OR, 1.10; p = 0.52).

conclusionDonor smoking was associated with reduced Hb increments and the need for additional transfusions in recipients of gamma-irradiated RBC units. Additional research is needed to better understand interactions between donor, component, and recipient factors on efficacy measures of RBC transfusion.

Indexed as

Blood DonorsErythrocyte TransfusionGamma RaysAdultErythrocytesFemaleHemoglobinsHumansMaleMiddle AgedRetrospective StudiesSmokingHemoglobins

Identifiers

PMID32358816
PMCPMC9250110
OpenAlexW3021564612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.