ArticleIndian journal of pediatrics2020
Neurological Manifestations of Influenza A (H1N1): Clinical Features, Intensive Care Needs, and Outcome.
Article in Indian journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Influenza-associated neurological complications in pediatric patients: clinical characteristics, outcomes, and the neuroinfluenza severity score in the multicenter TURK-INF study.European journal of pediatrics · 2026Article
- Influenza A virus infection impairs neuronal activity in human iPSC-derived NGN2 neural co-cultures.Acta neuropathologica communications · 2026Article
- Clinical characteristics and co-infection analysis of influenza a virus in pediatric respiratory infections: a study based on tNGS technology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Clinical Profile, Intensive Care Needs, and Outcome of Children with Adenoviral Pneumonia: A Retrospective Study from a Tertiary Care Hospital in North India.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- H1N1-associated acute leukoencephalopathy: An unusual presentation in a young adult indian male.IDCases · 2025Article
- Severe Neurological Complications With Influenza in Vietnamese Children.Influenza and other respiratory viruses · 2024Article
- SARS-CoV-2 EncephalitisCurrent pediatric reviews · 2024Review
- Bibliometric analysis of publication trends and topics of influenza-related encephalopathy from 2000 to 2022.Immunity, inflammation and disease · 2023Article
- Development of a nomogram for severe influenza in previously healthy children: a retrospective cohort study.The Journal of international medical research · 2023Review
- Modulating Neurological Complications of Emerging Infectious Diseases: Mechanistic Approaches to Candidate Phytochemicals.Frontiers in pharmacology · 2021Review
- Influenza Associated Neurological Diseases in Children.Indian journal of pediatrics · 2020Article
- Acute Necrotizing Encephalopathy of Childhood: A Rare Neurological Manifestation of Dengue.Annals of Indian Academy of NeurologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo describe neurological manifestations in children with Influenza A (H1N1).
methodsThis retrospective study was conducted in the Pediatric intensive care unit (PICU) and Pediatric Neurology unit of a tertiary care teaching hospital in North India involving children with PCR confirmed Influenza A (H1N1) with neurological manifestations during 2019 outbreak.
resultsSix children (5 females, 1 male) were enrolled. All presented with neurological symptoms (seizures and altered sensorium) accompanied with fever and respiratory symptoms with duration of illness of 2-7 d. The admission Glasgow Coma Scale ranged from 4 to 12. Only 2 cases showed cerebrospinal fluid pleocytosis. Neuroimaging was suggestive of diffuse cerebral edema, acute necrotizing encephalopathy of childhood, and acute disseminated encephalomyelitis. All were treated with Oseltamivir. Four cases had clinical features of raised intracranial pressure (ICP) and were managed in PICU, 3 of them needed mechanical ventilation, 3 needed vasoactive drugs, 3 received 3% saline infusion, 1 underwent invasive ICP monitoring, and 3 (cases 4, 5 and 6) received intravenous methylprednisolone (30 mg/kg) for 5 d. Total duration of hospital stay was 10-30 d. Case 2 expired due to refractory raised ICP. Among survivors, 3 children had residual neurological deficits and the remaining 2 had achieved premorbid condition.
conclusionsInfluenza A (H1N1) can present with isolated or predominant neurological manifestations which can contribute to poor outcome. The authors suggest to rule out H1N1 in any child who presents with unexplained neurological manifestations during seasonal outbreaks of H1N1.
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