Evidence map›Paper›PMID 32358767›Full record

ArticleNeurocritical care2021

Assessment of Brain Glucose Metabolism Following Cardiac Arrest by [

Hannah J Zhang, Samuel Mitchell, Yong-Hu Fang, Hsiu-Ming Tsai, Lin Piao, Alaa Ousta, Lara Leoni, Chin-Tu Chen, Willard W Sharp

Open access · greenAbstract read
In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Metabolism-Mediated Regulation of Brain-Heart Interactions.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hannah J ZhangDepartment of Radiology, University of Chicago, 5814 S Maryland Avenue, Chicago, IL, 60637, USA.
Samuel MitchellDepartment of Radiology, University of Chicago, 5814 S Maryland Avenue, Chicago, IL, 60637, USA.
Yong-Hu FangDepartment of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Hsiu-Ming TsaiOffice of Shared Research Facilities, University of Chicago, 5814 S Maryland Avenue, Chicago, IL, 60637, USA.
Lin PiaoDepartment of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Alaa OustaDepartment of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Lara LeoniOffice of Shared Research Facilities, University of Chicago, 5814 S Maryland Avenue, Chicago, IL, 60637, USA.
Chin-Tu ChenDepartment of Radiology, University of Chicago, 5814 S Maryland Avenue, Chicago, IL, 60637, USA.
Willard W SharpDepartment of Medicine, Section of Emergency Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. wsharp@medicine.bsd.uchicago.edu.ORCID http://orcid.org/0000-0002-7175-3523
University of Chicago · US

Funding

The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
Pharmacological Induced Torpor/Hypothermia As A Novel Therapy for Improving Post Cardiac Arrest Resuscitation OutcomesR01HL133675 · NHLBI · UNIVERSITY OF CHICAGO · PI SHARP, WILLARD WILLIAM · 2016 to 2020
$2.0M
Integrating Preclinical and Translational Imaging Resources for Animal ResearchS10OD025265 · OD · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU · 2018 to 2018
$319k
NCATS NIH HHS UL1 TR002389NHLBI NIH HHS R01 HL133675NHLBI NIH HHS T32 HL007381NIH HHS S10 OD025265
6 · The paper itself

Abstract

backgroundCardiac arrest (CA) patients who survived by cardiopulmonary resuscitation (CPR) can present different levels of neurological deficits ranging from minor cognitive impairments to persistent vegetative state and brain death. The pathophysiology of the resulting brain injury is poorly understood, and whether changes in post-CA brain metabolism contribute to the injury are unknown. Here we utilized [

methodsAnesthetized and ventilated adult C57BL/6 mice underwent 12-min KCl-induced CA followed by CPR. Seventy-two hours following CA, surviving mice were intraperitoneally injected with [

resultsGlobal increases in brain [

conclusionsThis study has successfully applied [

Indexed as

Fluorodeoxyglucose F18Heart ArrestAnimalsBrainGlucoseHumansMiceMice, Inbred C57BLPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionFluorodeoxyglucose F18GlucoseRadiopharmaceuticals[18F]Fluorodeoxyglucose (FDG)Brain glucose metabolismCardiac arrestCerebral injuryPositron emission tomography (PET)Resuscitation

Identifiers

PMID32358767
PMCPMC7606281
OpenAlexW3023274677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.