ArticleEnvironmental science and pollution research international2020
Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- NSAIDs in the environment: a 2020-2025 review of impacts on plant and algal Physiology.Ecotoxicology (London, England) · 2026Review
- Biotransformation of common NSAIDs by Cunninghamella species and resulting metabolite toxicity.Scientific reports · 2026Article
- Occurrence and risk assessment of pharmaceutical and personal care product pollution in Urban Aquatic Ecosystems of South India.Scientific reports · 2026Article
- Grey water footprint of pharmaceuticals and personal care products discharged via urban wastewater.Scientific reports · 2026Article
- G.AI.A: An Integrated Machine-Learning Platform for Predicting Bioaccumulation and Ecotoxicity of Pharmaceuticals.Journal of chemical information and modeling · 2026Article
- Review
- Green Solutions to a Growing Problem: Harnessing Plants for Antibiotic Removal from the Environment.Antibiotics (Basel, Switzerland) · 2025Review
- Removal of Ibuprofen from Contaminated Water by Bioaugmentation with Novel Bacterial Strains Isolated from Sewage Sludge.Microorganisms · 2025Article
- Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals.Environmental science & technology · 2023Review
- Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal.Frontiers in microbiology · 2023Review
- Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218.Applied and environmental microbiology · 2022Article
- Review
- Review
- Efficient degradation of various emerging pollutants by wild type and evolved fungal DyP4 peroxidases.PloS one · 2022Article
- Toxicity and remediation of pharmaceuticals and pesticides using metal oxides and carbon nanomaterials.Chemosphere · 2021Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
The intensive development of medical science has led to an increase in the availability and use of pharmaceutical products. However, nowadays, most of scientific attention has been paid to the native forms of pharmaceuticals, while the transformation products (TPs) of these substances, understood herein as metabolites, degradation products, and selected enantiomers, remain largely unexplored in terms of their characterization, presence, fate and effects within the natural environment. Therefore, the main aim of this study was to evaluate the toxicity of seven native compounds belonging to different therapeutic groups (non-steroidal anti-inflammatory drugs, opioid analgesics, beta-blockers, antibacterial and anti-epileptic drugs), along with the toxicity of their 13 most important TPs. For this purpose, an ecotoxicological test battery, consisting of five organisms of different biological organization was used. The obtained data shows that, in general, the toxicity of TPs to the tested organisms was similar or lower compared to their parent compounds. However, for example, significantly higher toxicity of the R form of ibuprofen to algae and duckweed, as well as a higher toxicity of the R form of naproxen to luminescent bacteria, was observed, proving that the risk associated with the presence of drug TPs in the environment should not be neglected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.