Evidence map›Paper›PMID 32358666›Full record

ArticleJournal of thrombosis and thrombolysis2020

AKT2 regulates endothelial-mediated coagulation homeostasis and promotes intrathrombotic recanalization and thrombus resolution in a mouse model of venous thrombosis.

Wanmu Xie, Lin Zhang, Wei Luo, Zhenguo Zhai, Chen Wang, Ying H Shen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Transforming Growth Factors in Venous Thrombus Formation and Resolution.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wanmu XieDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, BCM 390, Houston, TX, 77030, USA.
Lin ZhangDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, BCM 390, Houston, TX, 77030, USA.
Wei LuoDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, BCM 390, Houston, TX, 77030, USA.
Zhenguo ZhaiDepartment of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Hepingli, Beijing, 100029, China.
Chen WangNational Clinical Research Center for Respiratory Diseases, Beijing, China. cyh-birm@263.net.
Ying H ShenDivision of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, BCM 390, Houston, TX, 77030, USA. hyshen@bcm.edu.ORCID http://orcid.org/0000-0003-4119-115X
Baylor College of Medicine · USCapital Medical University · CN

Funding

Targeting ER Stress To Treat Aortic Aneurysms and DissectionsR01HL131980 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2016 to 2019
$1.7M
Mitochondrial Damage-Induced Necroptotic Cell Death in SporadicAscending Thoracic Aortic Aneurysms and DissectionsR01HL143359 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2018 to 2021
$1.6M
NEUTROPHIL DEPENDENT MEDIATION OF VASCULAR PERMEABILITYF32HL007301 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LEWIS, RUTH E · 1986 to 1987
–
American Heart Association AHA-0730190NHL HL143359HL HL-HL131980NHLBI NIH HHS R01 HL131980NHLBI NIH HHS R01 HL143359The National Key Technology R&D Program of the Ministry of Science and Technology 2012BAI05B02
6 · The paper itself

Abstract

Venous thromboembolism (VTE) carries a high risk of morbidity and mortality. Understanding the mechanisms of venous thrombus formation and resolution is critical for improving VTE management. AKT2 kinase is essential for platelet activation and arterial thrombosis. In this study, we examined the role of AKT2 in venous thrombosis in a mouse model of venous thrombosis induced by inferior vena cava (IVC) ligation. We observed an induction of AKT2 expression in the ligated IVC of wild-type (WT) mice. Interestingly, although the initial thrombus size of the ligated IVC was similar between Akt2

Indexed as

Venous ThrombosisAnimalsApoptosisBlood CoagulationDisease Models, AnimalEndothelial CellsHomeostasisMiceMice, KnockoutProto-Oncogene Proteins c-aktSignal TransductionThrombomodulinThromboplastinThrombosisAkt2 protein, mouseProto-Oncogene Proteins c-aktTHBD protein, mouseThrombomodulinThromboplastinAKTFOXO1ThrombomodulinTissue factorVenous thrombosis

Identifiers

PMID32358666
PMCPMC7335364
OpenAlexW3023208565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.