ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020
Microbial keratitis in Sydney, Australia: risk factors, patient outcomes, and seasonal variation.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Topical antibiotics for treating bacterial keratitis: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- TFOS lifestyle: Impact of societal challenges on the ocular surface.The ocular surface · 2023Pooled it
- Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Infectious bacterial keratitis management in a Swedish region: Risk factors, treatment and time-to-resolution.Acta ophthalmologica · 2026Article
- Emerging microfluidic diagnostic systems for anterior segment diseases: a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Evaluation of Antimicrobial Peptide-Antibiotic Combination Treatment for Tackling Ocular and SystemicInternational journal of molecular sciences · 2026Article
- Trends in pathogens causing microbial keratitis in studies conducted in Mexico: a 38-year literature review.International ophthalmology · 2026Review
- Epidemiology, Microbiology, Antimicrobial Resistance, and Outcomes of Corneal Ulcers: A 10-Year Retrospective Study in Indonesia.Korean journal of ophthalmology : KJO · 2026Article
- Antimicrobial activity of a short guanidine mimic immobilised on contact lenses.Journal of materials science. Materials in medicine · 2026Article
- Risk Factors and Common Organisms in Bacterial Keratitis in a Tertiary Center in Iran.Journal of ophthalmic & vision research · 2026Article
- Contact lens-related versus non-contact lens-relatedFrontiers in medicine · 2026Article
- From pathogen to prognosis: microbial keratitis spectrum and treatment outcomes in a 5-Year tertiary center experience.Journal of ophthalmic inflammation and infection · 2025Article
- Role of AS-OCT in assessment of healing of thin or perforated cornea treated by amniotic membrane graft and PRP clot.BMC ophthalmology · 2025Observational
- Comorbidities, clinical outcome and rate of herpes simplex positive PCR in patients with keratitis, corneal erosions and ulcers.Journal of ophthalmic inflammation and infection · 2025Article
- Shifting trends in bacterial keratitis in a referral center.International ophthalmology · 2025Article
- Aetiology and antibiotic susceptibility of bacterial keratitis at a referral centre in southern Sweden.Scientific reports · 2025Article
- First report of Stemphylium lycopersici keratitis, a complex corneal infection case.Journal of ophthalmic inflammation and infection · 2025Article
- The Temporal Distribution and Microbial Spectrum in Infectious Keratitis: A Comprehensive Single-Center Study.Journal of clinical medicine · 2025Article
- Microbial keratitis in north-western Spain: a review of risk factors, microbiological profile and resistance patterns.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo provide recent data on patient demographics, clinical profile and outcomes of patients with microbial keratitis over a 5-year period at the Sydney Eye Hospital, and to identify seasonal variations of the main causative organisms.
methodA retrospective study of patients with a clinical diagnosis of microbial keratitis and corneal scrape performed between 1 January 2012 and 31 December 2016. Clinical information was gathered from medical records and pathology data.
resultsOne thousand fifty-two eyes from 979 patients with a mean age of 54.7 ± 21.5 years (range 18-100 years) were included. The majority of cases were bacterial (65%) followed by polymicrobial (2.4%), fungi (2.3%), and culture-negative (31%). Common risk factors for microbial keratitis were contact lens wear (63%) and previous topical steroid use (24%). Factors significantly associated with poor patient outcomes in the multivariate model were age, visual acuity, and epithelial defect size (p < 0.05). Patients with fungal or polymicrobial keratitis presented with worse clinical features at initial and final presentation (p < 0.05). There was a significant variation in the occurrence of Pseudomonas aeruginosa (p = 0.018) and fungal keratitis (predominately made up of Candida and Fusarium species) (p = 0.056) in the hottest seasons.
conclusionPoorer outcomes are more likely to be seen in older patients and those presenting with poor visual acuity and large epithelial defects at the initial presentation.
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