Evidence map›Paper›PMID 32358642›Full record

ArticleJournal of neuro-oncology2020

Spine stereotactic radiosurgery for metastases from hepatobiliary malignancies: patient selection using PRISM scoring.

Olsi Gjyshi, David Boyce-Fappiano, Todd A Pezzi, Ethan B Ludmir, Lianchun Xiao, Ahmed Kaseb, Behrang Amini, Debra Nana Yeboa, Andrew J Bishop, Jing Li and 4 more

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In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Olsi GjyshiDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-2677-3058
David Boyce-FappianoDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.
Todd A PezziDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.
Ethan B LudmirDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.
Lianchun XiaoDepartment of Statistics, University of Texas MD Anderson Cancer Center, Houston, USA.
Ahmed KasebDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, USA.
Behrang AminiDepartment of Radiology, University of Texas MD Anderson Cancer Center, Houston, USA.
Debra Nana YeboaDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.
Andrew J BishopDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA.
Jing LiDepartment of Statistics, University of Texas MD Anderson Cancer Center, Houston, USA.
Laurence D RhinesDepartment of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, USA.
Claudio Esteves TatsuiDepartment of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, USA.
Tina Marie BriereDepartment of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, USA.
Amol Jitendra GhiaDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Y2.5329, Houston, TX, 77030, USA. AJGhia@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

objectiveDose escalation via stereotactic radiation therapy techniques has been necessary for hepatobiliary malignancies in the primary and oligometastatic setting, but such dose escalation is challenging for spine metastases due to spinal cord proximity. Here, we investigate the role of spine stereotactic radiosurgery (SSRS) in the management of such metastases.

methodsWe retrospectively reviewed patients treated with SSRS to spinal metastases from hepatobiliary malignancies between 2004 and 2017 at our Institution. We used the Kaplan-Meier method to calculate overall survival (OS) and local control (LC) and Cox regression analysis to identify factors associated with disease-related outcomes.

resultsWe identified 28 patients treated to 43 spinal metastases with SSRS for either HCC or cholangiocarcinoma. The 1-year LC and OS were 85% and 23%, respectively. The median time to death was 6.2 months, while median time to local failure was not reached. Tumor volume > 60 cc (SHR 6.65, p = 0.03) and Bilsky ≥ 1c (SHR 4.73, p = 0.05) predicted for poorer LC, while BED

conclusionSSRS provides durable local control in patients with metastatic hepatobiliary malignancies, with higher BED necessary to ensure excellent LC. PRISM scoring is a promising prognostic tool to aid SSRS patient selection.

Indexed as

RadiosurgeryAdultAgedDigestive System NeoplasmsFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPatient SelectionRetrospective StudiesSpinal NeoplasmsTreatment OutcomeHepatobiliary malignanciesPrognostic index score for spinal metastasesSBRTSSRS

Identifiers

PMID32358642
OpenAlexW3022472541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.