Evidence map›Paper›PMID 32358638›Full record

Trial reportWorld journal of surgery2020

Transcutaneous Stimulation of Auricular Branch of the Vagus Nerve Attenuates the Acute Inflammatory Response After Lung Lobectomy.

Mohamed Salama, Ahmet Akan, Michael Rolf Mueller

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03204968 (The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03204968 nacompletednot on this map

The Effect of Vagus Nerve Stimulation on the Inflammatory Response After Lung Lobectomy

TypeinterventionalSponsorOtto Wagner HospitalRan2015 to 2017Enrolled130ConditionsInflammatory ResponseArmsVagus nerve stimulation
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mohamed SalamaDepartment of Thoracic Surgery, North Clinic, Bruennerstrasse 68, 1210, Vienna, Austria.
Ahmet AkanDepartment of Thoracic Surgery, North Clinic, Bruennerstrasse 68, 1210, Vienna, Austria.
Michael Rolf MuellerDepartment of Thoracic Surgery, North Clinic, Bruennerstrasse 68, 1210, Vienna, Austria. michael.rolf.mueller@wienkav.at.
Anton Bruckner Private University · ATSigmund Freud University Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSystemic inflammation is a potentially debilitating complication of thoracic surgeries with significant physical and economic morbidity. There is compelling evidence for the role of the central nervous system in regulating inflammatory processes through humoral mechanisms. Activation of the afferent vagus nerve by cytokines triggers anti-inflammatory responses. Peripheral electrical stimulation of the vagus nerve in vivo during lethal endotoxemia in rats inhibited tumor necrosis factor synthesis and prevented shock development. However, the vagal regulatory role of systemic inflammation after lung lobectomy is unknown.

methodsOne hundred patients who underwent lobectomy via thoracotomy were recruited and equally randomized to treated group or controls. Intermittent stimulation of the auricular branch of vagus nerve in the triangular fossa was applied in the treated group using neurostimulator V (Ducest

resultsOn the 1st POD, patients who underwent neurostimulation had reduced serum concentrations of CRP (p = 0.01), IL6 (p = 0.02) but elevated IL10 (p = 0.03) versus controls. On the 4th POD, serum concentrations of CRP, IL6 and IL10 were similar in both groups. Moreover, the treated group was associated with lower incidence of pneumonia (p = 0.04) and shorter hospitalization time (p = 0.04) versus controls.

conclusionsModulations in the brain stem caused by noninvasive transcutaneous stimulation of the vagus nerve after lung lobectomy attenuate the acute postsurgical inflammatory response by the regulation of IL6 and IL10, resulting in  reduced incidence of postoperative pneumonia and short hospitalization time. CLINICAL TRIAL REGISTRY NUMBER: NCT03204968.

Indexed as

AnimalsFemaleHumansLungLung NeoplasmsMaleMiddle AgedPneumonectomyPostoperative CareRatsTranscutaneous Electric Nerve StimulationVagus NerveVagus Nerve Stimulation

Identifiers

PMID32358638
OpenAlexW3021557246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.