ArticleNPJ biofilms and microbiomes2020
Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds.
Article in NPJ biofilms and microbiomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06310239 (Osseointegrated Limb Implant Microbiome Population Adaptation Study), which is not on this map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Osseointegrated Limb Implant Microbiome Population Adaptation Study
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- The association between pressure injury microbiome and wound healing: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Review
- Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration.Journal of materials science. Materials in medicine · 2026Article
- Genomic Epidemiology of Fungi Identified in Bronchoalveolar Lavage Fluid from Asthmatic Horses in the US.Animals : an open access journal from MDPI · 2026Article
- Advances in Versatile Copper Sulfide-Based Nanoplatforms: From Synthesis and Properties to Multifaceted Biomedical Applications.International journal of nanomedicine · 2026Review
- Beyond susceptibility testing: traditional Chinese medicine-associated compounds as candidate antibiotic adjuncts in chronic-wound biofilms.Frontiers in cellular and infection microbiology · 2026Review
- 16S rRNA sequencing and conventional culture provide complementary information in hospitalized patients with chronic lower-limb wounds.Frontiers in cellular and infection microbiology · 2026Article
- A longitudinal profiling of microbiome of diabetic foot ulcers shows functional role of microbial communities in wound worsening and chronicity.Current research in microbial sciences · 2026Article
- The Role of the Microbiome in the Resolution of Infection-Induced Inflammation.ACS infectious diseases · 2025Review
- Integration of localized microbiome, metabolome, and clinical datasets predicts healing in chronic wounds among veterans.bioRxiv : the preprint server for biology · 2025Article
- Roll-To-Roll Production of Smart Dressings for Wound Monitoring.Advanced healthcare materials · 2025Article
- The Role of Natural Hydrogels in Enhancing Wound Healing: From Biomaterials to Bioactive Therapies.Pharmaceutics · 2025Review
- Curcumin-Loaded Drug Delivery Systems for Acute and Chronic Wound Management: A Review.Bioengineering (Basel, Switzerland) · 2025Review
- Plant Extracts as Modulators of the Wound Healing Process-Preliminary Study.International journal of molecular sciences · 2025Article
- The wound microbiome associated with deep sternal wound infection: a scoping review.Journal of thoracic disease · 2025Review
- Skin-associated commensal microorganisms and their metabolites.Journal of applied microbiology · 2025Review
- Optimization and Preparation of Polysaccharide-Protamine Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing.Marine drugs · 2025Article
- A STRUCTURAL EQUATION MODEL PREDICTS CHRONIC WOUND HEALING TIME USING PATIENT CHARACTERISTICS AND WOUND MICROBIOME COMPOSITION.medRxiv : the preprint server for health sciences · 2025Article
- Sparse Bayesian Group Factor Model for Feature Interactions in Multiple Count Tables Data.Journal of the American Statistical Association · 2025Article
- Finite element and preclinical analysis of tissue response to negative pressure wound therapy with a felted foam containing 10 mm through holes.Frontiers in bioengineering and biotechnology · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic wounds represent a large and growing disease burden. Infection and biofilm formation are two of the leading impediments of wound healing, suggesting an important role for the microbiome of these wounds. Debridement is a common and effective treatment for chronic wounds. We analyzed the bacterial content of the wound surface from 20 outpatients with chronic wounds before and immediately after debridement, as well as healthy skin. Given the large variation observed among different wounds, we introduce a Bayesian statistical method that models patient-to-patient variability and identify several genera that were significantly enriched in wounds vs. healthy skin. We found no difference between the microbiome of the original wound surface and that exposed by a single episode of sharp debridement, suggesting that this debridement did not directly alter the wound microbiome. However, we found that aerobes and especially facultative anaerobes were significantly associated with wounds that did not heal within 6 months. The facultative anaerobic genus Enterobacter was significantly associated with lack of healing. The results suggest that an abundance of facultative anaerobes is a negative prognostic factor in the chronic wound microbiome, possibly due to the increased robustness of such communities to different metabolic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.