Evidence map›Paper›PMID 32358489›Full record

ArticleNature communications2020

Mega macromolecules as single molecule lubricants for hard and soft surfaces.

Parambath Anilkumar, Taylor B Lawson, Srinivas Abbina, Janne T A Mäkelä, Robert C Sabatelle, Lily E Takeuchi, Brian D Snyder, Mark W Grinstaff, Jayachandran N Kizhakkedathu

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Biomacromolecules · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Parambath Anilkumar *Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-4898-0565
Taylor B Lawson *Department of Mechanical Engineering, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4674-545X
Srinivas Abbina *Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-9103-7444
Janne T A Mäkelä *Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6123-1262
Robert C SabatelleDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Lily E TakeuchiCentre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-9527-8042
Brian D SnyderCenter for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mark W GrinstaffDepartment of Mechanical Engineering, Boston University, Boston, MA, USA. mgrin@bu.edu.ORCID http://orcid.org/0000-0002-5453-3668
Jayachandran N KizhakkedathuCentre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada. jay@pathology.ubc.ca.ORCID http://orcid.org/0000-0001-7688-7574
Boston University · USUniversity of British Columbia · CAUniversity of British Columbia Hospital · CA

Funding

Translational Research in BiomaterialsT32EB006359 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MARK W. GRINSTAFF, Michelle H Teplensky · 2009 to 2026
$4.2M
Synthesis, Characterization, and Evaluation of Polymeric Tissue LubricantsR01AR066621 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GRINSTAFF, MARK W., SNYDER, BRIAN D · 2014 to 2017
$1.5M
GAG Mimetic Interpenetrating Network for the Repair of Osteoarthritic CartilageF31AR075386 · NIAMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LAWSON, TAYLOR · 2019 to 2021
$121k
CIHRNIAMS NIH HHS F31 AR075386NIAMS NIH HHS R01 AR066621NIBIB NIH HHS T32 EB006359
6 · The paper itself

Abstract

A longstanding goal in science and engineering is to mimic the size, structure, and functionality present in biology with synthetic analogs. Today, synthetic globular polymers of several million molecular weight are unknown, and, yet, these structures are expected to exhibit unanticipated properties due to their size, compactness, and low inter-chain interactions. Here we report the gram-scale synthesis of dendritic polymers, mega hyperbranched polyglycerols (mega HPGs), in million daltons. The mega HPGs are highly water soluble, soft, nanometer-scale single polymer particles that exhibit low intrinsic viscosities. Further, the mega HPGs are lubricants acting as interposed single molecule ball bearings to reduce the coefficient of friction between both hard and soft natural surfaces in a size dependent manner. We attribute this result to their globular and single particle nature together with its exceptional hydration. Collectively, these results set the stage for new opportunities in the design, synthesis, and evaluation of mega polymers.

Indexed as

DendrimersGlycerolLubricantsMacromolecular SubstancesNanotechnologyPolymersSurface PropertiesDendrimersGlycerolLubricantsMacromolecular SubstancespolyglycerolPolymers

Identifiers

PMID32358489
PMCPMC7195476
OpenAlexW3022729230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.