Evidence map›Paper›PMID 32358216›Full record

ArticleNeurology2020

The CREST-2 experience with the evolving challenges of COVID-19: A clinical trial in a pandemic.

James F Meschia, Kevin M Barrett, Robert D Brown, Tanya N Turan, Virginia J Howard, Jenifer H Voeks, Brajesh K Lal, George Howard, Thomas G Brott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. CREST-2 Reaches A Surgical Milestone.Journal of vascular surgery · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James F MeschiaFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park. meschia.james@mayo.edu.ORCID 0000-0002-4475-8142
Kevin M BarrettFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
Robert D BrownFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
Tanya N TuranFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
Virginia J HowardFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.ORCID 0000-0003-4912-9975
Jenifer H VoeksFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
Brajesh K LalFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
George HowardFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.
Thomas G BrottFrom the Department of Neurology (J.F.M., K.M.B., T.G.B.), Mayo Clinic, Jacksonville, FL; Department of Neurology (R.D.B.), Mayo Clinic, Rochester, MN; Department of Neurology (T.N.T., J.H.V.), Medical University of South Carolina, Charleston; Department of Epidemiology (V.J.H.) and Department of Biostatistics (G.H.), University of Alabama at Birmingham; Department of Surgery (B.K.L.), University of Maryland, College Park.ORCID 0000-0002-1266-0941

Funding

CREST-2 Clinical Coordinating CenterU01NS080168 · NINDS · MAYO CLINIC JACKSONVILLE · PI Thomas G Brott, JAMES F MESCHIA · 2014 to 2026
$56.3M
NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
CREST-2 Statistical and Data Coordinating Center - SDCCU01NS080165 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI EDWARDS, LLOYD J · 2014 to 2025
$15.0M
NINDS NIH HHS U01 NS080165NINDS NIH HHS U01 NS080168NINDS NIH HHS U01 NS086872
6 · The paper itself

Abstract

The coronavirus disease 2019 pandemic has disrupted the lives of whole communities and nations. The multinational multicenter National Institute of Neurological Disorders and Stroke Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial stroke prevention trial rapidly experienced the effects of the pandemic and had to temporarily suspend new enrollments and shift patient follow-up activities from in-person clinic visits to telephone contacts. There is an ethical obligation to the patients to protect their health while taking every feasible step to ensure that the goals of the trial are successfully met. Here, we describe the effects of the pandemic on the trial and steps that are being taken to mitigate the effects of the pandemic so that trial objectives can be met.

Indexed as

PandemicsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAsymptomatic DiseasesBetacoronavirusCanadaCarotid StenosisCommunicable Disease ControlComorbidityCoronavirus InfectionsCOVID-19Diabetes MellitusDyslipidemiasElective Surgical ProceduresAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor Blockers

Identifiers

PMID32358216
PMCPMC7371383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.