Evidence map›Paper›PMID 32358066›Full record

ArticleThe Journal of biological chemistry2020

Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.

David B Melville, Sean Studer, Randy Schekman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  7. Functional overlap between the mammalianProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  10. Functional overlap between the mammalianbioRxiv : the preprint server for biology · 2024
    Article
  11. ER exit in physiology and disease.Frontiers in molecular biosciences · 2024
    Review
  12. Article
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  14. Article
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  19. ER exit sites take the strain.The EMBO journal · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David B MelvilleDepartment of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0001-6686-0992
Sean StuderDepartment of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA.
Randy SchekmanDepartment of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA schekman@berkeley.edu.ORCID 0000-0001-8615-6409
Howard Hughes Medical Institute · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Vesicles that are coated by coat protein complex II (COPII) are the primary mediators of vesicular traffic from the endoplasmic reticulum to the Golgi apparatus. Secretion-associated Ras-related GTPase 1 (SAR1) is a small GTPase that is part of COPII and, upon GTP binding, recruits the other COPII proteins to the endoplasmic reticulum membrane. Mammals have two SAR1 paralogs that genetic data suggest may have distinct physiological roles,

Indexed as

Amino Acid SequenceAnimalsBinding SitesCell LineCRISPR-Cas SystemsDimerizationGene EditingGuanosine TriphosphateHumansMolecular Dynamics SimulationMonomeric GTP-Binding ProteinsPhylogenyProtein BindingProtein Conformation, alpha-HelicalRecombinant Fusion ProteinsSequence AlignmentGuanosine TriphosphateMonomeric GTP-Binding ProteinsRecombinant Fusion ProteinsSAR1A protein, humanSAR1B protein, humanSEC23A protein, humanSEC31A protein, humanVesicular Transport ProteinsapolipoproteinCOPIIGTPaseintracellular traffickingmembrane traffickingSAR1ASAR1BSEC23SEC31secretion

Identifiers

PMID32358066
PMCPMC7307210
OpenAlexW3022181360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.