Evidence map›Paper›PMID 32358064›Full record

ArticleThe Journal of biological chemistry2020

Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids.

Mansoore Esmaili, Brian P Tancowny, Xiongyao Wang, Audric Moses, Leonardo M Cortez, Valerie L Sim, Holger Wille, Michael Overduin

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Deciphering the language of mingling lipids and proteins.Current opinion in structural biology · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Detergent-Free Membrane Protein Purification Using SMA Polymer.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  6. Article
  7. Biological insights from SMA-extracted proteins.Biochemical Society transactions · 2021
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mansoore EsmailiDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-5197-7255
Brian P TancownyDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Xiongyao WangDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.
Audric MosesLipidomics Core Facility, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Leonardo M CortezCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
Valerie L SimCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.
Holger WilleDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada overduin@ualberta.ca wille@ualberta.ca.
Michael OverduinDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada overduin@ualberta.ca wille@ualberta.ca.ORCID 0000-0002-3114-6585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prions are lipidated proteins that interact with endogenous lipids and metal ions. They also assemble into multimers and propagate into the infectious scrapie form known as PrP

Indexed as

AnimalsBrainCricetinaeLipidsMaleatesMethylaminesMiceNanostructuresPhospholipidsPolystyrenesPrion ProteinsSulfhydryl CompoundsLipidsMaleatesmethylamineMethylaminesPhospholipidsPolystyrenesPrion Proteinsstyrene-maleic acid polymerSulfhydryl Compoundslipidlipid binding proteinlipid-protein interactionmembrane proteinnanotechnologynative nanodiscneurodegenerative diseaseprionprotein misfoldingSMALPstyrene maleic acid copolymerstyrene–maleic acid lipid particle (SMALP)

Identifiers

PMID32358064
PMCPMC7307199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.