Evidence map›Paper›PMID 32358041›Full record

ArticleJournal of the American Society of Nephrology : JASN2020

Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid-Mediated Activation of G Protein-Coupled Receptors GPR43 and GPR109A.

Yan Jun Li, Xiaochen Chen, Tony K Kwan, Yik Wen Loh, Julian Singer, Yunzi Liu, Jin Ma, Jian Tan, Laurence Macia, Charles R Mackay and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 5 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 5 syntheses or guidelines pooled it, 344 citations in OpenAlex.

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  14. The roles of free-fatty acid receptors in the pathophysiology of renal disorders.The Journal of pharmacology and experimental therapeutics · 2026
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168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yan Jun LiKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia huiling.wu@sydney.edu.au.ORCID 0000-0001-5128-139X
Xiaochen ChenKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Tony K KwanKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-1952-4264
Yik Wen LohKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Julian SingerKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-1855-3581
Yunzi LiuKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Jin MaKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia huiling.wu@sydney.edu.au.
Jian TanNutritional Immunometabolism Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-1359-1797
Laurence MaciaNutritional Immunometabolism Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Charles R MackayInfection and Immunity Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
Steven J ChadbanKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Huiling WuKidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia huiling.wu@sydney.edu.au.
The University of Sydney · AUAustralian Regenerative Medicine Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have reported "dysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty acids (SCFAs) through gut fermentation of fiber, in CKD and diabetes. Dietary fiber is associated with decreased inflammation and mortality in CKD, and SCFAs have been proposed to mediate this effect.

methodsTo explore dietary fiber's effect on development of experimental diabetic nephropathy, we used streptozotocin to induce diabetes in wild-type C57BL/6 and knockout mice lacking the genes encoding G protein-coupled receptors GPR43 or GPR109A. Diabetic mice were randomized to high-fiber, normal chow, or zero-fiber diets, or SCFAs in drinking water. We used proton nuclear magnetic resonance spectroscopy for metabolic profiling and 16S ribosomal RNA sequencing to assess the gut microbiome.

resultsDiabetic mice fed a high-fiber diet were significantly less likely to develop diabetic nephropathy, exhibiting less albuminuria, glomerular hypertrophy, podocyte injury, and interstitial fibrosis compared with diabetic controls fed normal chow or a zero-fiber diet. Fiber beneficially reshaped gut microbial ecology and improved dysbiosis, promoting expansion of SCFA-producing bacteria of the genera

conclusionsDietary fiber protects against diabetic nephropathy through modulation of the gut microbiota, enrichment of SCFA-producing bacteria, and increased SCFA production. GPR43 and GPR109A are critical to SCFA-mediated protection against this condition. Interventions targeting the gut microbiota warrant further investigation as a novel renoprotective therapy in diabetic nephropathy.

Indexed as

AlbuminuriaAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesDietary FiberDysbiosisFatty Acids, VolatileGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLReceptors, G-Protein-CoupledStreptozocinDietary FiberFatty Acids, VolatileFfar2 protein, mouseHcar2 protein, mouseReceptors, G-Protein-CoupledStreptozocinchronic inflammationdiabetic nephropathymetabolism

Identifiers

PMID32358041
PMCPMC7269358
OpenAlexW3023205828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.