Evidence map›Paper›PMID 32357948›Full record

ArticleVeterinary research2020

Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies.

Carolina Cubillos-Zapata, Iván Angulo, Horacio Almanza, Belén Borrego, María Zamora-Ceballos, José R Castón, Ignacio Mena, Esther Blanco, Juan Bárcena

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 34 citations in OpenAlex.

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  13. Isolation, Identification, and Genetic Evolution Analysis ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Carolina Cubillos-ZapataCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
Iván AnguloCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
Horacio AlmanzaCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
Belén BorregoCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
María Zamora-CeballosCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
José R CastónDepartment of Structure of Macromolecules, Centro Nacional de Biotecnología/CSIC, Cantoblanco, Madrid, Spain.
Ignacio MenaCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
Esther BlancoCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain.
Juan BárcenaCentro de Investigación en Sanidad Animal, INIA-CISA, Valdeolmos, Madrid, Spain. barcena@inia.es.ORCID http://orcid.org/0000-0001-6050-0654
Centro de Investigación en Sanidad AnimalCentro Nacional de Biotecnología · ESCentro Regional de Selección y Reproducción Animal · ESHospital La Paz Institute for Health Research · ESUniversidad Autónoma de Baja California · MX

Funding

Comunidad Autónoma de Madrid P2018/BAA-4370 PLATESAComunidad Autónoma de Madrid P2018/NMT-4389Spanish Ministry of Economy and Competitivity AGL2016-76445-RSpanish Ministry of Economy and Competitivity BFU2017-88736-RSpanish Ministry of Science and Innovation BES-2017-081188
6 · The paper itself

Abstract

We report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5'HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recognized by non-neutralizing MAbs; and a second epitope spanning amino acids 445-451 (ITTANQY), highly variable and recognized by neutralizing MAbs. These antibodies might be valuable for diagnostic applications, as well as for further research in different aspects of the biology of FCV.

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralCalicivirus, FelineCapsidEpitopesAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralEpitopes

Identifiers

PMID32357948
PMCPMC7195702
OpenAlexW3022893728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.