ArticleEuropean heart journal2020
Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization.
Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Coffee and Risk of Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization Analyses.Nutrients · 2024Pooled it
- Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort.Pediatric nephrology (Berlin, Germany) · 2026Article
- Higher systemic vascular resistance in individuals with a family history of hypertension.Journal of hypertension · 2025Article
- Polygenic Determinants of Arterial Stiffness: Implications for Hypertension.medRxiv : the preprint server for health sciences · 2025Article
- The effects of Songling Xuemaikang capsule on vascular remodeling of stage 1 hypertension: a multicenter, randomized placebo-controlled trial protocol.BMC complementary medicine and therapies · 2025Article
- Temporal and joint associations of hypertension and estimated pulse wave velocity with incident cardiovascular diseases: a population-based cohort study.European journal of medical research · 2025Article
- Association between arterial stiffness and MASLD in US young adults: base on NHANES 2005-2018.American journal of preventive cardiology · 2025Article
- Similarity of immune-associated markers in COVID-19 and Kawasaki disease: analyses from bioinformatics and machine learning.BMC pediatrics · 2025Article
- Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study.Journal of pain research · 2025Article
- Effects of intravenous pulse methylprednisolone in neuromyelitis optica during the acute phase.Annals of clinical and translational neurology · 2024Article
- The U -shape relationship between free fatty acid level and adverse outcomes in coronary artery disease patients with hypertension: evidence from a large prospective cohort study.Lipids in health and disease · 2024Article
- Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.PLoS genetics · 2024Article
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- Article
- Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet.American journal of physiology. Heart and circulatory physiology · 2023Review
- Relation of Pulse Wave Velocity to Contemporaneous and Historical Blood Pressure in Female Twins.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Establishment and evaluation of nomogram for predicting intraventricular hemorrhage in neonatal acute respiratory distress syndrome.BMC pediatrics · 2023Article
- Association of baseline and dynamic arterial stiffness status with dyslipidemia: a cohort study.Frontiers in endocrinology · 2023Article
- Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort.Frontiers in epidemiology · 2023Article
- Intrarenal Dopaminergic System Is Dysregulated in SS-Biomedicines · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimsHaemodynamic determinants of blood pressure (BP) include cardiac output (CO), systemic vascular resistance (SVR), and arterial stiffness. We investigated the heritability of these phenotypes, their association with BP-related single-nucleotide polymorphisms (SNPs), and the causal association between BP and arterial stiffness. METHODS AND
resultsWe assessed BP, central BP components, and haemodynamic properties (during a single visit) including CO, SVR, and pulse wave velocity (PWV, measure of arterial stiffness) in 3531 (1934 monozygotic, 1586 dizygotic) female TwinsUK participants. Heritability was estimated using structural equation modelling. Association with 984 BP-associated SNP was examined using least absolute shrinkage and selection operator (LASSO) and generalized estimating equation regression. One and two-sample Mendelian randomization (MR) was used to estimate the causal direction between BP and arterial stiffness including data on 436 419 UK Biobank participants. We found high heritability for systolic and pulsatile components of BP (>50%) and PWV (65%) with overlapping genes accounting for >50% of their observed correlation. Environmental factors explained most of the variability of CO and SVR (>80%). Regression identified SNPs (n = 5) known to be associated with BP to also be associated with PWV. One-sample MR showed evidence of bi-directional causal association between BP and PWV in TwinsUK participants. Two-sample MR, confirmed a bi-directional causal effect of PWV on BP (inverse variance weighted (IVW) beta = 0.11, P < 0.02) and BP on arterial stiffness (IVW beta = 0.004, P < 0.0001).
conclusionThe genetic basis of BP is mediated not only by genes regulating BP but also by genes that influence arterial stiffness. Mendelian randomization indicates a bi-directional causal association between BP and arterial stiffness.
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