ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2020
Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Pooled it
- Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.Translational psychiatry · 2021Pooled it
- Childhood paternal abuse and low paternal affection predict adult panic symptoms 18 years later via actigraphy-indexed sleep disruptions.Psychological medicine · 2026Article
- Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits.Molecular psychiatry · 2025Article
- Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood.Nature communications · 2025Article
- Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems.Molecular psychiatry · 2024Article
- Direct and Indirect Genetic Effects on Aggression.Biological psychiatry global open science · 2023Article
- Preliminary Evidence for Genetic Nurture in Depression and Neuroticism Through Polygenic Scores.JAMA psychiatry · 2023Article
- The influence of genetic and acquired factors on the vulnerability to develop depression: a review.Bioscience reports · 2023Review
- Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?Translational psychiatry · 2023Article
- Why we need families in genomic research on developmental psychopathology.JCPP advances · 2023Article
- Overview of CAPICE-Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe-an EU Marie Skłodowska-Curie International Training Network.European child & adolescent psychiatry · 2022Review
- Intergenerational transmission of parental neuroticism to emotional problems in 8-year-old children: Genetic and environmental influences.JCPP advances · 2021Article
- Article
- Maternal and paternal effects on offspring internalizing problems: Results from genetic and family-based analyses.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and their covariance on offspring internalizing problems were estimated in 3,801 mother-father-child genotyped trios. Next, estimated genetic correlations within pedigree data, including 10,688 children, were used to estimate additive genetic effects, maternal and paternal genetic effects, and a shared family effect using linear mixed effects modeling. There were no significant maternal or paternal genetic effects on offspring anxiety or depressive symptoms at age 8, beyond the effects transmitted via the genetic pathway between parents and children. However, indirect maternal genetic effects explained a small, but nonsignificant, proportion of variance in childhood depressive symptoms in both the M-GCTA (~4%) and pedigree (~8%) analyses. Our results suggest that parental effects on offspring internalizing problems are predominantly due to transmitted genetic variants, rather than the indirect effect of parental genes via the environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.