Evidence map›Paper›PMID 32356911›Full record

ArticleDevelopmental science2021

Multifactorial pathways facilitate resilience among kindergarteners at risk for dyslexia: A longitudinal behavioral and neuroimaging study.

Jennifer Zuk, Jade Dunstan, Elizabeth Norton, Xi Yu, Ola Ozernov-Palchik, Yingying Wang, Tiffany P Hogan, John D E Gabrieli, Nadine Gaab

Open access · greenAbstract read
In one paragraph

Article in Developmental science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  4. Longitudinal trajectories of brain development from infancy to school age and their relationship with literacy development.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jennifer ZukLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Jade DunstanLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Elizabeth NortonDepartment of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
Xi YuLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-0818-1451
Ola Ozernov-PalchikMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yingying WangDepartment of Special Education and Communication Disorders, University of Nebraska - Lincoln, Lincoln, NE, USA.
Tiffany P HoganDepartment of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA, USA.
John D E GabrieliMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nadine GaabLaboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-7548-413X
Boston Children's Hospital · USMcGovern Institute for Brain Research · USMGH Institute of Health Professions · USNorthwestern University · USUniversity of Nebraska–Lincoln · US

Funding

TRAINING FOR SPEECH AND HEARING SCIENCEST32DC000038 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gwenaelle S Geleoc · 1992 to 2026
$21.8M
Longitudinal Study of childhood fMRI markers prior to reading onsetR01HD065762 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GAAB, NADINE, GRANT, PATRICIA ELLEN · 2011 to 2021
$6.3M
Using Cognitive Neuroscience to Predict Dyslexia among Kindergarden ChildrenR01HD067312 · NICHD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GAAB, NADINE, GABRIELI, JOHN · 2011 to 2015
$3.1M
Examining behavioral and neural links between speech delay and literacy skillsF31DC015919 · NIDCD · HARVARD MEDICAL SCHOOL · PI ZUK, JENNIFER MARGARET · 2016 to 2016
$31k
NICHD NIH HHS R01 HD065762NICHD NIH HHS R01 HD067312NIDCD NIH HHS F31 DC015919NIDCD NIH HHS T32 DC000038
6 · The paper itself

Abstract

Recent efforts have focused on screening methods to identify children at risk for dyslexia as early as preschool/kindergarten. Unfortunately, while low sensitivity leads to under-identification of at-risk children, low specificity can lead to over-identification, resulting in inaccurate allocation of limited educational resources. The present study focused on children identified as at-risk in kindergarten who do not subsequently develop poor reading skills to specify factors associated with better reading outcomes among at-risk children. Early screening was conducted in kindergarten and a subset of children was tracked longitudinally until second grade. Potential protective factors were evaluated at cognitive-linguistic, environmental, and neural levels. Relative to at-risk kindergarteners with subsequent poor reading, those with typical reading outcomes were characterized by significantly higher socioeconomic status (SES), speech production accuracy, and structural organization of the posterior right-hemispheric superior longitudinal fasciculus (SLF). A positive association between structural organization of the right SLF and subsequent decoding skills was found to be specific to at-risk children and not observed among typical controls. Among at-risk children, several kindergarten-age factors were found to significantly contribute to the prediction of subsequent decoding skills: white matter organization in the posterior right SLF, age, gender, SES, and phonological awareness. These findings suggest that putative compensatory mechanisms are already present by the start of kindergarten. The right SLF, in conjunction with the cognitive-linguistic and socioeconomic factors identified, may play an important role in facilitating reading development among at-risk children. This study has important implications for approaches to early screening, and assessment strategies for at-risk children.

Indexed as

DyslexiaWhite MatterAwarenessChildChild, PreschoolHumansLongitudinal StudiesNeuroimagingReadingDTIdyslexiaresilienceriskscreeningwhite matter

Identifiers

PMID32356911
PMCPMC7606625
OpenAlexW3022206490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.