Relative Contributions of Anatomical and Quantum Noise in Signal Detection and Perception of Tomographic Digital Breast Images.

Anatomical and quantum noise inhibits detection of malignancies in clinical images such as in digital mammography (DM), digital breast tomosynthesis (DBT) and breast CT (bCT). In this work, we examine the relative influence and interactions of these two types of noise on the task of low contrast mass detectability in DBT. We show how the changing levels of quantum noise contributes to the estimated power-law slope β by changing DBT acquisition parameters as well as with spatial filtering like an adaptive Weiner filtering. Finally, we examine via human observer LROC studies whether power spectral parameters obtained from DBT images correlate with mass detectability in those images. Our results show that lower values of power-law slope β can result from heightened quantum noise or image artifacts and do not necessarily imply reduced anatomical noise or improved signal detectability for the given imaging system. These results strengthen the argument that when power-law magnitude K is varying, β is less relevant to lesion detectability. Our preliminary results also point to K values having strong correlation to human observer performance, at least for the task shown in this paper. As a byproduct of these main results, we also show that while changes in acquisition geometry can improve mass detectability, the use of efficient filters like an adaptive Weiner filtering can significantly improve the detection of low contrast masses in DBT.