ArticleeLife2020
Expansion microscopy of
Open access · goldAbstract readVideo-Audio Media
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 99 citations in OpenAlex.
- Thousandfold Expansion Microscopy.bioRxiv : the preprint server for biology · 2026Article
- Super-resolution expansion microscopy reveals nanoscale protein domains and CObioRxiv : the preprint server for biology · 2026Article
- RBMP2 shapes specialized membranes for CObioRxiv : the preprint server for biology · 2026Article
- Expansion Microscopy reveals changes in cellular and extracellular structures between healthy and perturbed tendons.bioRxiv : the preprint server for biology · 2026Article
- Whole-organism spatial transcriptomics at single-cell resolution inbioRxiv : the preprint server for biology · 2026Article
- Developing a Robust Multiround HCR-FISH Method Modified for Caenorhabditis elegans.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Expansion omics: from expansion microscopy to spatial omics.Molecular systems biology · 2026Review
- Principles ofbioRxiv : the preprint server for biology · 2026Article
- Plants in the expansion era: recent advances in expansion microscopy in plant systems.Journal of experimental botany · 2025Review
- All-optical visualization of specific molecules in the ultrastructural context of brain tissue.Nature biotechnology · 2025Article
- Super-resolution expansion microscopy in plant roots.The Plant cell · 2025Article
- Bio-orthogonal Glycan Imaging of Cultured Cells and Whole AnimalACS central science · 2025Article
- Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues.Nature communications · 2025Article
- Imaging and Quantifying Mitochondrial Morphology in C. elegans During Aging.Journal of visualized experiments : JoVE · 2025Article
- Expansion microscopy reveals neural circuit organization in genetic animal models.Neurophotonics · 2025Review
- Accelerated protein retention expansion microscopy using microwave radiation.Cell reports methods · 2024Article
- Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain.Nature communications · 2024Article
- Single-shot 20-fold expansion microscopy.Nature methods · 2024Article
- Surpassing the Diffraction Limit in Label-Free Optical Microscopy.ACS photonics · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 1 country.
Chih-Chieh Jay YuDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-8713-0446
Nicholas C BarryMedia Lab, Massachusetts Institute of Technology, Cambridge, United States.
Asmamaw T WassieDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.
Anubhav SinhaMedia Lab, Massachusetts Institute of Technology, Cambridge, United States.
Abhishek BhattacharyaDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Shoh AsanoMedia Lab, Massachusetts Institute of Technology, Cambridge, United States.
Chi ZhangMedia Lab, Massachusetts Institute of Technology, Cambridge, United States.
Fei ChenBroad Institute of MIT and Harvard, Cambridge, United States.
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-7634-2854
Miriam B GoodmanDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, United States.ORCID 0000-0002-5810-1272
Gal HaspelFederated Department of Biological Sciences, New Jersey Institute of Technology and Rutgers University-Newark, Newark, United States.ORCID 0000-0001-6701-697X
Edward S BoydenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-0419-3351
McGovern Institute for Brain Research · USHoward Hughes Medical Institute · USBroad Institute · USPfizer (United States) · USRutgers, The State University of New Jersey · USStanford University · US
Funding
Center for Genomically Engineered OrgansRM1HG008525 · NHGRI · HARVARD MEDICAL SCHOOL · PI CHURCH, GEORGE M · 2015 to 2019
$10.2MRecording neural activities onto DNAR01MH103910 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BOYDEN, EDWARD S., CHURCH, GEORGE M · 2013 to 2017
$9.5MNovel Platforms for Systematic Optical Control of Complex Neural Circuits In VivoR01DA029639 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2010 to 2023
$6.7MThe biophysics of skin-neuron sensory tactile organs and their sensitivity to mechanical and chemical stressR35NS105092 · NINDS · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B · 2018 to 2025
$6.4MExpansion MicroscopyR01EB024261 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2025
$4.6MNeuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8MRNA Scaffolds for Cell Specific Multiplexed Neural ObservationR01MH114031 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$2.8MAn Accessible Optical Toolbox for Saturated Nanoscale Analysis of Neural ArchitectureR01MH110932 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOYDEN, EDWARD S., CAI, DAWEN · 2016 to 2019
$2.8MArmy Research Office W911NF1510548Intelligence Advanced Research Projects Activity D16PC00008National Science Foundation 1734870NHGRI NIH HHS RM1 HG008525NIBIB NIH HHS R01 EB024261NIBIB NIH HHS T32 EB001680NIDA NIH HHS R01 DA029639NIH HHS 1R01MH103910NIMH NIH HHS R01 MH103910NIMH NIH HHS R01 MH110932NIMH NIH HHS R01 MH114031NINDS NIH HHS R35 NS105092U.S. Army Research Laboratory W911NF1510548
Abstract
We recently developed expansion microscopy (ExM), which achieves nanoscale-precise imaging of specimens at ~70 nm resolution (with ~4.5x linear expansion) by isotropic swelling of chemically processed, hydrogel-embedded tissue. ExM of
Indexed as
Caenorhabditis elegansMicroscopy, FluorescenceAnimalsAnimals, Genetically ModifiedCaenorhabditis elegans ProteinsConnexinsDNAFluorescent Antibody TechniqueLuminescent ProteinsNanotechnologyNeuronsRNASynapsesTissue FixationCaenorhabditis elegans ProteinsConnexinsDNALuminescent ProteinsRNAC. elegansdevelopmental biologyexpansion microscopygene expressionimmunohistochemistryin situ hybridizationneurosciencesuper-resolution imagingsynapses
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.