ArticleJournal of the American Chemical Society2020
Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs.
Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Bottom-up Strategies for Generating Polymer Protocells That Mimic Cellular Communication.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Photoactivatable Synthetic Exosomes for RNA-Based Communication Between Artificial Cells and Living Cells.Angewandte Chemie (International ed. in English) · 2025Article
- Spatiotemporal Control Over Protein Release from Artificial Cells via a Light-Activatable Protease.Advanced biology · 2025Article
- Adaptive ATP-induced molecular condensation in membranized protocells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Competitive protein recruitment in artificial cells.Communications chemistry · 2024Article
- Tuning interfacial fluidity and colloidal stability of membranized coacervate protocells.Communications chemistry · 2024Article
- Models of Chemical Communication for Micro/Nanoparticles.Accounts of chemical research · 2024Article
- Regulating Chemokine-Receptor Interactions through the Site-Specific Bioorthogonal Conjugation of Photoresponsive DNA Strands.Bioconjugate chemistry · 2023Article
- Autonomic Integration in Nested Protocell Communities.Journal of the American Chemical Society · 2023Article
- Membranized Coacervate Microdroplets: from Versatile Protocell Models to Cytomimetic Materials.Accounts of chemical research · 2023Review
- Signal processing and generation of bioactive nitric oxide in a model prototissue.Nature communications · 2022Article
- Tetraphenylethylene-DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles.Organic & biomolecular chemistry · 2022Article
- DNA-Mediated Protein Shuttling between Coacervate-Based Artificial Cells.Angewandte Chemie (International ed. in English) · 2022Article
- Triggerable Protocell Capture in Nanoparticle-Caged Coacervate Microdroplets.Journal of the American Chemical Society · 2022Article
- Nanoprogrammed Cross-Kingdom Communication Between Living Microorganisms.Nano letters · 2022Article
- Chemical Communication in Artificial Cells: Basic Concepts, Design and Challenges.Frontiers in molecular biosciences · 2022Review
- Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets.Nature communications · 2021Article
- Dynamic self-assembly of compartmentalized DNA nanotubes.Nature communications · 2021Article
- Dynamic spatial and structural organization in artificial cells regulates signal processing by protein scaffolding.Chemical science · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The programmed construction of functional synthetic cells requires spatial control over arrays of biomolecules within the cytomimetic environment. The mimicry of the natural hierarchical assembly of biomolecules remains challenging due to the lack of an appropriate molecular toolbox. Herein, we report the implementation of DNA-decorated supramolecular assemblies as dynamic and responsive nanoscaffolds for the localization of arrays of DNA signal cargo within hierarchically assembled complex coacervate protocells. Protocells stabilized with a semipermeable membrane allow trafficking of single-stranded DNA between neighboring protocells. DNA duplex operations demonstrate the responsiveness of the nanoscaffolds to different input DNA strands via the reversible release of DNA cargo. Moreover, a second population of coacervate protocells with nanoscaffolds featuring a higher affinity for the DNA cargo enabled chemically programmed communication between both protocell populations. This combination of supramolecular structure and function paves the way for the next generation of protocells imbued with programmable, lifelike behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.