ArticleAmerican journal of Alzheimer's disease and other dementias
A Metabolic Imaging Study of Lexical and Phonological Naming Errors in Alzheimer Disease.
Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Mapping the neural correlates of the effect of psycholinguistic variables on picture naming performance: a FDG-PET study across neurodegenerative diseases.Alzheimer's research & therapy · 2025Article
- Articulatory and phonological performance in people with mild cognitive impairment and Alzheimer's disease: A scoping review.Journal of Alzheimer's disease reports · 2024Review
- Brain Areas Critical for Picture Naming: A Systematic Review and Meta-Analysis of Lesion-Symptom Mapping Studies.Neurobiology of language (Cambridge, Mass.) · 2023Article
- The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach.Brain sciences · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Alzheimer disease (AD) produce a variety of errors on confrontation naming that indicate multiple loci of impairment along the naming process in this disease. We correlated brain hypometabolism, measured with 18fluoro-deoxy-glucose positron emission tomography, with semantic and formal errors, as well as nonwords deriving from phonological errors produced in a picture-naming test by 63 patients with AD. Findings suggest that neurodegeneration leads to: (1) phonemic errors, by interfering with phonological short-term memory, or with control over retrieval of phonological or prearticulatory representations, within the left supramarginal gyrus; (2) semantic errors, by disrupting general semantic or visual-semantic representations at the level of the left posterior middle and inferior occipitotemporal cortex, respectively; (3) formal errors, by damaging the lexical-phonological output interface in the left mid-anterior segment of middle and superior temporal gyri. This topography of semantic-lexical-phonological steps of naming is in substantial agreement with dual-stream neurocognitive models of word generation.
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Registered trials
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