Evidence map›Paper›PMID 32356305›Full record

ArticleInternational journal of cancer2020

A demonstration of automated visual evaluation of cervical images taken with a smartphone camera.

Zhiyun Xue, Akiva P Novetsky, Mark H Einstein, Jenna Z Marcus, Brian Befano, Peng Guo, Maria Demarco, Nicolas Wentzensen, Leonard Rodney Long, Mark Schiffman and 1 more

Registry-linked trialOpen access · bronzeAbstract readEvaluation Study
In one paragraph

Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06815939 (Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06815939 narecruitingnot on this mapstarted 2025, after this paper: background citation

Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer: Automated Visual Evaluation

TypeinterventionalSponsorDL AnalyticsRan2025 to 2026Enrolled10,000ConditionsHuman Papillomavirus (HPV), Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms, Cervical CancersArmsHPV Test, EVA System, Visual Inspection with Acetic Acid (VIA), Automated Visual Evaluation (AVE), Image Capture with Mobile Phone
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Zhiyun XueLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-0644-385X
Akiva P NovetskyRutgers New Jersey Medical School, Cancer Institute of New Jersey (CINJ), Newark, New Jersey, USA.
Mark H EinsteinRutgers New Jersey Medical School, Cancer Institute of New Jersey (CINJ), Newark, New Jersey, USA.
Jenna Z MarcusRutgers New Jersey Medical School, Cancer Institute of New Jersey (CINJ), Newark, New Jersey, USA.
Brian BefanoInformation Management Services, Inc, Rockville, Maryland, USA.
Peng GuoLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Maria DemarcoNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Nicolas WentzensenNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-1251-0836
Leonard Rodney LongLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Mark SchiffmanNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sameer AntaniLister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USRutgers, The State University of New Jersey · USInformation Management Services · US

Funding

Machine learning and artificial intelligence research for clinical medical image processingZIALM010018 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2021 to 2025
$9.0M
Image analysis and machine learning for cervical cancer diagnosticsZIALM010014 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2018 to 2020
$1.7M
Intramural NIH HHS Z99 LM999999Intramural NIH HHS ZIA LM010014Intramural NIH HHS ZIA LM010018NCI NIH HHSNLM NIH HHS
6 · The paper itself

Abstract

We examined whether automated visual evaluation (AVE), a deep learning computer application for cervical cancer screening, can be used on cervix images taken by a contemporary smartphone camera. A large number of cervix images acquired by the commercial MobileODT EVA system were filtered for acceptable visual quality and then 7587 filtered images from 3221 women were annotated by a group of gynecologic oncologists (so the gold standard is an expert impression, not histopathology). We tested and analyzed on multiple random splits of the images using two deep learning, object detection networks. For all the receiver operating characteristics curves, the area under the curve values for the discrimination of the most likely precancer cases from least likely cases (most likely controls) were above 0.90. These results showed that AVE can classify cervix images with confidence scores that are strongly associated with expert evaluations of severity for the same images. The results on a small subset of images that have histopathologic diagnoses further supported the capability of AVE for predicting cervical precancer. We examined the associations of AVE severity score with gynecologic oncologist impression at all regions where we had a sufficient number of cases and controls, and the influence of a woman's age. The method was found generally resilient to regional variation in the appearance of the cervix. This work suggests that using AVE on smartphones could be a useful adjunct to health-worker visual assessment with acetic acid, a cervical cancer screening method commonly used in low- and middle-resource settings.

Indexed as

BiopsyCervix UteriDatasets as TopicDeep LearningDiagnosis, DifferentialFemaleHumansImage Processing, Computer-AssistedMass ScreeningROC CurveSmartphoneUterine Cervical DysplasiaUterine Cervical Neoplasmsautomated visual evaluationcervical cancer screeningdeep learningsmartphone camera

Identifiers

PMID32356305
PMCPMC11977665
OpenAlexW3022143870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.