ArticleBreast cancer research and treatment2020
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study.
Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 27 citations in OpenAlex.
- The proportion, clinical predictors, and prognostic impact of hypometabolic estrogen receptor-positive primary breast cancer on baseline [ 18 F] fluorodeoxyglucose PET.Nuclear medicine communications · 2026Article
- Breast cancer incidence and survival by subtype, stage at diagnosis and socioeconomic deprivation among young women in the Community of Madrid, Spain.International journal of cancer · 2026Article
- Economic evaluation of automated scalp cooling systems for breast cancer patients in Spain.Health economics review · 2026Article
- Socioeconomic inequalities in adherence to clinical practice guidelines and breast cancer survival: a multicentre population-based study in Spain.BMJ quality & safety · 2025Article
- Comprehensive survival analysis of breast cancer patients: a bayesian network approach.BMC medical informatics and decision making · 2025Article
- Personalized mutation tracking in circulating-tumor DNA predicts recurrence in patients with high-risk early breast cancer.NPJ breast cancer · 2025Article
- Circulating miRNAs signature on breast cancer: the MCC-Spain project.European journal of medical research · 2023Article
- Clinicopathological Factors Affecting Breast Cancer Survival in Jamaican Women: A Retrospective Review.Journal of racial and ethnic health disparities · 2023Article
- Digital Health Literacy and Person-Centred Care: Co-Creation of a Massive Open Online Course for Women with Breast Cancer.International journal of environmental research and public health · 2023Article
- Expression and prognosis analysis of mitochondrial ribosomal protein family in breast cancer.Scientific reports · 2022Article
- Definition of High-Risk Early Hormone-Positive HER2-Negative Breast Cancer: A Consensus Review.Cancers · 2022Review
- Comprehensive Stability Study of Vitamin D3 in Aqueous Solutions and Liquid Commercial Products.Pharmaceutics · 2021Article
- Article
- Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up).International journal of environmental research and public health · 2020Article
- Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study.International journal of environmental research and public health · 2020Article
- Identifying Risk Factors for Regional Recurrence in Early-Stage Breast Cancer with pT1-2 and Negative Sentinel Lymph Node Biopsy.Cancer management and research · 2020Article
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Authors and funding
25 authors at 14 institutions in 2 countries.
Funding
Abstract
purposeThe objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score.
methodsThe breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors.
resultsAmong components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively.
conclusionBoth TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.
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