Evidence map›Paper›PMID 32356199›Full record

ArticleNeurochemical research2020

LncRNA H19 Attenuates Apoptosis in MPTP-Induced Parkinson's Disease Through Regulating miR-585-3p/PIK3R3.

Yong Zhang, Qiming Xia, Jun Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Epigenetic mechanisms of Parkinson's disease and potential epigenetic-based therapeutics.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Blood Pressure and Late Pregnancy Circulating miRNAs in the MADRES Study.Journal of the American Heart Association · 2025
    Article
  8. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  9. Review
  10. The landscape of programmed cell death-related lncRNAs in Alzheimer's disease and Parkinson's disease.Apoptosis : an international journal on programmed cell death · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Long Non-Coding RNAs: New Insights in Neurodegenerative Diseases.International journal of molecular sciences · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yong ZhangDepartment of Neurosurgery, Guizhou People's Hospital, No. 83, Zhongshang East Road, Nanming District, Guiyang, 550002, Guizhou, China.
Qiming XiaDepartment of Neurosurgery, Guizhou People's Hospital, No. 83, Zhongshang East Road, Nanming District, Guiyang, 550002, Guizhou, China.
Jun LinDepartment of Neurosurgery, Guizhou People's Hospital, No. 83, Zhongshang East Road, Nanming District, Guiyang, 550002, Guizhou, China. JunLinfio@163.com.ORCID http://orcid.org/0000-0002-7157-2554
Guizhou Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent age-related neurodegenerative disease which is modulated by various molecules, including long non-coding RNAs (lncRNAs). LncRNA H19 has been shown to be associated with PD progression, but the mechanism is still unclear. This research aims to investigate the role of H19 in PD development and the detailed mechanisms. Our results showed that H19 was down-regulated in brain tissue of MPTP-induced PD mice (in vivo) and in MPP

Indexed as

AnimalsApoptosisCell Line, TumorHEK293 CellsHumansMaleMiceMice, Inbred C57BLMicroRNAsMPTP PoisoningPhosphatidylinositol 3-KinasesRNA, Long NoncodingH19 long non-coding RNAMicroRNAsMIRN585 microRNA, humanPhosphatidylinositol 3-Kinasespik3r3 protein, mouseRNA, Long NoncodingLncRNA H19miR-585-3pParkinson's diseasePIK3R3

Identifiers

PMID32356199
OpenAlexW3021125250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.