Evidence map›Paper›PMID 32356175›Full record

ArticleJournal of cancer research and clinical oncology2020

Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers.

Eric Adjei Boakye, Maggie Wang, Arun Sharma, Wiley D Jenkins, Nosayaba Osazuwa-Peters, Betty Chen, Minjee Lee, Mario Schootman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  6. Article
  7. Has the National Fall in Smoking Rates in Ireland Been Replicated in Cancer Patients? A 5-Year Report.International journal of environmental research and public health · 2022
    Article
  8. A Systematic Review of Artificial Intelligence Techniques in Cancer Prediction and Diagnosis.Archives of computational methods in engineering : state of the art reviews · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eric Adjei BoakyeDepartment of Population Science and Policy, Southern Illinois University School of Medicine, 201 E. Madison Street, P. O. Box 19664, Springfield, IL, 62794, USA. eadjeiboakye49@siumed.edu.ORCID http://orcid.org/0000-0001-9163-8103
Maggie WangSaint Louis University School of Medicine, Saint Louis, MO, USA.
Arun SharmaDepartment of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
Wiley D JenkinsDepartment of Population Science and Policy, Southern Illinois University School of Medicine, 201 E. Madison Street, P. O. Box 19664, Springfield, IL, 62794, USA.
Nosayaba Osazuwa-PetersDepartment of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, St. Louis, MO, USA.
Betty ChenDepartment of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA.
Minjee LeeDepartment of Population Science and Policy, Southern Illinois University School of Medicine, 201 E. Madison Street, P. O. Box 19664, Springfield, IL, 62794, USA.
Mario SchootmanDepartment of Clinical Analytics and Insights, Center for Clinical Excellence, SSM Health, Saint Louis, MO, USA.
Southern Illinois University School of Medicine · USSaint Louis University · USSSM Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs the number of cancer survivors in the United States increases, quantifying the risks and burden of second primary cancers (SPCs) among cancer survivors will help develop long-term prevention and surveillance strategies. We describe the risk of developing a SPC among survivors of 10 cancer sites with the highest survival rates in the United States.

methodsAdult patients diagnosed with an index smoking-related (urinary bladder, kidney and renal pelvis, uterine cervix, oral cavity and pharynx, and colon and rectum) and index non-smoking-related (prostate, thyroid, breast, corpus and uterus, and non-Hodgkin lymphoma) cancers were identified from Surveillance, Epidemiology, and End Results (2000-2015). SPC risks were quantified using standardized incidence ratios (SIRs) and excess absolute risks (EARs) per 10,000 person-years at risk (PYR).

resultsA cohort of 2,903,241 patients was identified and 259,685 (8.9%) developed SPC (7.6% of women and 10.3% of men). All index cancer sites (except prostate) were associated with a significant increase in SPC risk for women and men. Patients diagnosed with smoking-related index cancers (SIR range 1.20-2.16 for women and 1.12-1.91 for men) had a higher increased risk of SPC than patients with non-smoking-related index cancers (SIR range 1.08-1.39 for women and 1.23-1.38 for men) relative to the general population.

conclusionWe found that 1-in-11 cancer survivors developed a SPC. Given the increasing number of cancer survivors and the importance of SPC as a cause of cancer death, there is a need for increased screening for and prevention of SPC.

Indexed as

AdultAgedDisease SusceptibilityFemaleHumansIncidenceMaleMiddle AgedNeoplasmsNeoplasms, Second PrimaryRisk AssessmentRisk FactorsSEER ProgramSmokingCancer survivorsMalignant neoplasmSecond primary cancerSmoking-associated cancersSurveillance Epidemiology and End Results (SEER) program

Identifiers

PMID32356175
PMCPMC11804670
OpenAlexW3023843682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.