Influence of pancreatic status, CFTR mutations, Staphylococcus aureus and/or Pseudomonas aeruginosa infection/colonization on lung function in cystic fibrosis during a 2-year follow-up period.

Maíra Andrade Pascoal, Fernando Augusto Lima Marson, Ilma Aparecida Paschoal, Carlos Emílio Levy

Abstract read

In one paragraph

Article in Wiener klinische Wochenschrift, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maíra Andrade PascoalDepartment of Pediatrics, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, Cidade Universitária Zeferino Vaz, Barão Geraldo, ZIP CODE: 13083-887, Campinas, São Paulo, Brazil.

Fernando Augusto Lima MarsonDepartment of Pediatrics, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, Cidade Universitária Zeferino Vaz, Barão Geraldo, ZIP CODE: 13083-887, Campinas, São Paulo, Brazil. fernandolimamarson@hotmail.com.

Ilma Aparecida PaschoalDepartment of Clinical Medicine, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, Cidade Universitária Zeferino Vaz, Barão Geraldo, ZIP CODE: 13083-887, Campinas, São Paulo, Brazil.

Carlos Emílio LevyDepartment of Clinical Pathology, Faculty of Medical Sciences, University of Campinas, Tessália Vieira de Camargo Street, 126, Cidade Universitária Zeferino Vaz, Barão Geraldo, ZIP CODE: 13083-887, Campinas, São Paulo, Brazil. levy.carlosemilio@gmail.com.

Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCystic fibrosis (CF) presents with progressive and chronic deterioration of lung function due to inflammation and colonization/infection of the lungs. This study evaluated spirometry and colonization/infection with Staphylococcus aureus and/or Pseudomonas aeruginosa over a 24-month follow-up period.

methodsA total of 52 CF patients were studied with spirometry: forced vital capacity (FVC), forced expiratory volume in one second of FVC (FEV

resultsIn CF, there was a higher prevalence of p.Phe508del/p.Phe508del genotype (16/52; 30.8%) and female gender (33/52; 63.5%). Spirometry (% predicted) markers worsened for the following groups over the 24-month period: (i) male: FVC, FEV

conclusionIn CF, deterioration of lung function as evaluated by spirometry was continuous and varied according to sex, pancreatic insufficiency, and severe CFTR mutations. No differences were observed between groups in terms of predominant type of bacteria, but the reduction of spirometry parameters was significant in the predominantly S. aureus and concomitant infection groups.

Indexed as

Cystic FibrosisPseudomonas InfectionsCystic Fibrosis Transmembrane Conductance RegulatorFemaleFollow-Up StudiesHumansLungMaleMutationPseudomonas aeruginosaSpirometryStaphylococcus aureusCystic Fibrosis Transmembrane Conductance RegulatorBacteriaGenotype-PhenotypeLung DiseaseMicrorganismSpirometry

Identifiers

PMID32356101

DOI10.1007/s00508-020-01660-7

OpenAlexW3022093183

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.