ArticleVirchows Archiv : an international journal of pathology2020
Histological changes associated with pyloric and pseudopyloric metaplasia after Helicobacter pylori eradication.
Article in Virchows Archiv : an international journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Endoscopic spectrum of autoimmune gastritis across disease stages: a focus on Barrett's esophagus and ME-NBI features.Frontiers in immunology · 2026Article
- Autoimmune gastritis: clinical and histological study in a Peruvian population.BMC gastroenterology · 2025Article
- A case of gastric adenocarcinoma with pyloric gland-type infiltrating submucosa.Surgical case reports · 2024Article
- Clinicopathological characteristics of pancreatic acinar cell metaplasia associated with Helicobacter pylori infection.BMC gastroenterology · 2022Article
- LGR5-Expressing Cells in the Healing Process of Post-ESD Ulcers in Gastric Corpus.Digestive diseases and sciences · 2022Article
- Sporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda.BMC gastroenterology · 2022Article
- Gastric epithelial histology and precancerous conditions.World journal of gastrointestinal oncology · 2022Review
- Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.Virchows Archiv : an international journal of pathology · 2021Article
- Biologic profiles meet clinical priorities: incorporating pseudopyloric, and spasmolytic-expressing metaplasia in the assessment of gastric atrophy.Virchows Archiv : an international journal of pathology · 2020Article
- Regression of Autoimmune Gastritis after Eradication ofCase reports in gastroenterologyArticle
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10 authors at 2 institutions in 1 country.
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Abstract
Pyloric metaplasia (PM) and pseudopyloric metaplasia (PPM) are metaplastic changes resulting in pyloric-type glands in the gastric oxyntic mucosa that mainly occur in chronic gastritis caused by Helicobacter pylori (H. pylori) infection. Focusing on PM and PPM, we classified the histological changes in gastric mucosa according to the Updated Sydney System, using 314 biopsy specimens of gastric greater curvature of the middle body before H. pylori eradication (HPE). Next, the numbers of PM and PPM glands were counted in 47 specimens, and subjects were followed up over 10 years after HPE. PPM was recognized jointly with inflammation, activity, atrophy, and intestinal metaplasia, but PM was recognized more frequently than PPM as atrophy and intestinal metaplasia progressed. Both PM and PPM regressed significantly within 6 years after HPE. Additionally, we demonstrated that PM and PPM are not always coincident with spasmolytic polypeptide-expressing metaplasia (SPEM). In conclusion, PM and PPM are considered different modulations of the same line of differentiation, which are both reversible, with PM potentially emerging from PPM upon progression.
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