Evidence map›Paper›PMID 32356020›Full record

ArticleJournal of molecular evolution2020

FLAVI: An Amino Acid Substitution Model for Flaviviruses.

Thu Kim Le, Le Sy Vinh

Abstract read
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In one paragraph

Article in Journal of molecular evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Protein Evolution in the Flaviviruses.Journal of molecular evolution · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thu Kim LeUniversity of Engineering and Technology, Vietnam National University Hanoi, 144 Xuan Thuy, Cau Giay, Hanoi, 10000, Vietnam.
Le Sy VinhUniversity of Engineering and Technology, Vietnam National University Hanoi, 144 Xuan Thuy, Cau Giay, Hanoi, 10000, Vietnam. vinhls@vnu.edu.vn.ORCID 0000-0002-9060-9199

Funding

National Foundation for Science and Technology Development (VN) 102.01.2019.06
6 · The paper itself

Abstract

Amino acid substitution models represent substitution rates among amino acids during the evolution. The models play an important role in analyzing protein sequences, especially inferring phylogenies. The rapid evolution of flaviviruses is expanding the threat in public health. A number of models have been estimated for some viruses, however, they are unable to properly represent amino acid substitution patterns of flaviviruses. In this study, we collected protein sequences from the flavivirus genus to specifically estimate an amino acid substitution model, called FLAVI, for flaviviruses. Experiments showed that the collected dataset was sufficient to estimate a stable model. More importantly, the FLAVI model was remarkably better than other existing models in analyzing flavivirus protein sequences. We recommend researchers to use the FLAVI model when studying protein sequences of flaviviruses or closely related viruses.

Indexed as

Amino Acid SubstitutionFlavivirusModels, GeneticAmino Acid SequenceAmino acid substitution modelDengue virusEvolutionFlavivirusesWest nile virusZika virus

Identifiers

PMID32356020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.