Evidence map›Paper›PMID 32355910›Full record

ArticleAdvances in pharmacological and pharmaceutical sciences2020

Novel Dimethylacetamide-Containing Formulation Improves Infraorbital Anaesthesia Efficacy in Rats with Periodontitis.

Ekaterina V Blinova, Evgeniia V Shikh, Elena V Semeleva, Aleksandra M Yurochkina, Andrey V Novikov, Anna P Vediaeva, Arkadii B Lebedev, Elena G Lobanova, Olga V Vasilkina, Dmitry S Blinov and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in pharmacological and pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ekaterina V BlinovaDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Evgeniia V ShikhDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Elena V SemelevaDepartment of Dentistry, Department of Ophthalmology, National Research Mordovia State University, Saransk 430005, Russia.
Aleksandra M YurochkinaDepartment of Pharmaceutical Chemistry and Drug Design, All-Union Scientific Center of Biological Active Compounds, Staraja Kupavna 142450, Russia.
Andrey V NovikovDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Anna P VediaevaDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Arkadii B LebedevDepartment of Pharmacology, Tver State Medical University, Tver 170100, Russia.
Elena G LobanovaDepartment of Pharmacology, A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow 119983, Russia.
Olga V VasilkinaDepartment of Dentistry, Department of Ophthalmology, National Research Mordovia State University, Saransk 430005, Russia.
Dmitry S BlinovDepartment of Pharmaceutical Chemistry and Drug Design, All-Union Scientific Center of Biological Active Compounds, Staraja Kupavna 142450, Russia.ORCID https://orcid.org/0000-0002-8385-4356
Yan A MazovDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Evgeniia A KoganDepartment of Operative Surgery and Clinical Anatomy, Department of Pathology, Department of Dentistry, Sechenov University, Moscow 119991, Russia.
Sechenov University · RUNational Research Mordovia State University · RUMoscow State University of Medicine and Dentistry · RUTver State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate acute toxicity and local anaesthetic activity of a formulation containing a novel dimethylacetamide derivative, antioxidant, and vasoconstrictor in rats with chronic periodontitis.

methodsNovel anaesthetic dimethylacetamide-containing formulation LHT-15-32 was studied as 2% water solution. Its acute intravenous and subcutaneous toxicity was determined in mice. Pain sensitivity threshold of the upper second molar was determined in rats with experimental periodontitis. Oxidative stress activity and total antioxidant capacity were determined in rats' gingival mucosa by induced chemiluminescence. Local changes were evaluated in periodontal tissue by morphological examination. Tissue IL-1

resultsLHT-15-32 acute intravenous and subcutaneous toxicity was lower than that of its active substance. The formulation by infraorbital administration induced deep dental anaesthesia which lasted over 70 min and activated the local antioxidant defense system and decreased IL-1

conclusionsThe formulation may be considered as an effective and safe approach to anaesthetize upper molars with periodontitis.

Identifiers

PMID32355910
PMCPMC7178499
OpenAlexW3017083377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.