ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Intrathecal
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 25 citations in OpenAlex.
- Noninvasive whole-brain imaging of glymphatic dynamics.Science advances · 2026Article
- CSF outflow from the human spinal canal: preliminary results from an anatomical specimen-based model.Fluids and barriers of the CNS · 2025Article
- Evaluating the effect of injection protocols on intrathecal solute dispersion in non-human primates: an in vitro study using a cynomolgus cerebrospinal fluid system.Fluids and barriers of the CNS · 2024Article
- In vivo distribution of cerebrospinal fluid tracer in human upper spinal cord and brain stem.JCI insight · 2023Article
- Radionuclide Cisternography with [Pharmaceuticals (Basel, Switzerland) · 2023Article
- Plasma neurodegeneration biomarker concentrations associate with glymphatic and meningeal lymphatic measures in neurological disorders.Nature communications · 2023Article
- Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics.Pharmaceutics · 2023Review
- Whole CNS 3D Cryo-Fluorescence Tomography Shows CSF Clearance along Nasal Lymphatics, Spinal Nerves, and Lumbar/Sacral Lymph Nodes.Journal of imaging · 2023Article
- Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Review
- SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline.iScience · 2022Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders.Fluids and barriers of the CNS · 2022Article
- Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology.Fluids and barriers of the CNS · 2022Article
- Investigation of Human Intrathecal Solute Transport Dynamics Using a NovelFrontiers in neuroimaging · 2022Article
- Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood.JCI insight · 2021Article
- Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics.Cellular and molecular life sciences : CMLS · 2021Review
- Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution.Cerebral circulation - cognition and behavior · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches.
methodsFollowing intrathecal (ITH) dosing via lumbar puncture, Technetium-99 m (
resultsRostral cranial DISCUSSION: Widely used for detecting CSF leaks, ITH
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.