Evidence map›Paper›PMID 32355868›Full record

ArticleMolecular therapy. Methods & clinical development2020

DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

Jennifer E Adair, Mark R Enstrom, Kevin G Haworth, Lauren E Schefter, Reza Shahbazi, Daniel R Humphrys, Shaina Porter, Kenric Tam, Matthew H Porteus, Hans-Peter Kiem

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The p53 challenge of hematopoietic stem cell gene editing.Molecular therapy. Methods & clinical development · 2023
    Review
  7. Article
  8. Evaluation of diversity indices to estimate clonal dominance in gene therapy studies.Molecular therapy. Methods & clinical development · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Interrogation of clonal tracking data usingNature computational science · 2021
    Article
  13. Article
  14. Human gene therapy · 2021
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer E AdairClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Mark R EnstromClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Kevin G HaworthClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lauren E SchefterClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Reza ShahbaziClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Daniel R HumphrysClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Shaina PorterDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Kenric TamDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Matthew H PorteusDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA.
Hans-Peter KiemClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Stem cell expansion and gene editing in a nonhuman primate model of HIV/AIDSU19HL129902 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIEM, HANS-PETER · 2015 to 2019
$12.8M
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1M
Engraftment and in vivo selection of HIV-protected stem cellsR01HL116217 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2012 to 2017
$3.8M
Evaluation of Pluripotent Stem Cell-Derived Blood Cells in Nonhuman Primate ModelR01HL115128 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2013 to 2016
$3.3M
NCI NIH HHS P30 CA015704NHLBI NIH HHS R01 HL115128NHLBI NIH HHS R01 HL116217NHLBI NIH HHS U19 HL129902NIDDK NIH HHS U54 DK106829
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32355868
PMCPMC7184234

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.