Evidence map›Paper›PMID 32355824›Full record

ArticleAnnals of translational medicine2020

The genetic association between type 2 diabetic and hepatocellular carcinomas.

Zhan Shi, Zunqiang Xiao, Linjun Hu, Yuling Gao, Junjun Zhao, Yang Liu, Guoliang Shen, Qiuran Xu, Dongsheng Huang

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Zhan ShiThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310014, China.
Zunqiang XiaoThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310014, China.
Linjun HuThe Medical College of Qingdao University, Qingdao 266071, China.
Yuling GaoDepartment of Genetic Laboratory, Shaoxing Women and Children Hospital, Shaoxing 312030, China.
Junjun ZhaoGraduate Department, Bengbu Medical College, Bengbu 233030, China.
Yang LiuThe Medical College of Qingdao University, Qingdao 266071, China.
Guoliang ShenDepartment of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Qiuran XuThe Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, China.
Dongsheng HuangThe Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou 310014, China.
Qingdao University · CNZhejiang Chinese Medical University · CNZhejiang Provincial People's Hospital · CNBengbu Medical College · CNHangzhou Medical College · CNShaoxing City Women and Children Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) and hepatocellular carcinoma (HCC) are both major health problems throughout the world. It has been reported that T2DM is an independent risk factor for HCC, although the pathophysiology is still unclear.

methodsIn order to identify differentially expressed genes (DEGs) in T2DM and HCC, gene expression datasets for T2DM (GSE15653), HCC (GSE60502) and metformin-treated cells (GSE69850) were obtained from the Gene Expression Omnibus database repository. Protein-protein interaction (PPI) networks for the DEGs were constructed and gene clusters selected for functional enrichment analysis. Ten genes with the highest degree of connectivity were selected as hub genes and prognostic analysis together with analysis of gene expression and protein distribution were performed for these genes. Lastly, we investigated associations between the hub genes and genes associated with metformin treatment in hepatocarcinoma cells.

resultsIn total, 256 common DEGs, including 155 up-regulated genes and 101 down-regulated genes, were identified. Enrichment analyses showed that the genes of the major module were largely associated with the cell cycle. All of the 10 hub genes (

conclusionsThis study identified a number of genes that may play important roles in the association of T2DM and HCC, including four genes which may be the target of metformin treatment for diabetes and HCC. The specific mechanisms involved remain to be identified.

Indexed as

differentially expressed genehepatocellular carcinoma (HCC)MetforminType 2 diabetes mellitus (T2DM)

Identifiers

PMID32355824
PMCPMC7186634
OpenAlexW3011334017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.