Evidence map›Paper›PMID 32355724›Full record

ArticleAnnals of translational medicine2020

Effect of high flow nasal cannula on peripheral muscle oxygenation and hemodynamic during paddling exercise in patients with chronic obstructive pulmonary disease: a randomized controlled trial.

Tien-Pei Fang, Yen-Huey Chen, Hsiu-Feng Hsiao, Hsiu-Ying Cho, Ying-Huang Tsai, Chung-Chi Huang, Meng-Jer Hsieh, Huang-Pin Wu, Hui-Ling Lin

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07613762 (Effect of High-Flow Nasal Cannula Use on Exercise Tolerance and Physical Performance in Heart Failure Patients Enrolled in a Cardiac Rehabilitation Program), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07613762 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of High-Flow Nasal Cannula Use on Exercise Tolerance and Physical Performance in Heart Failure Patients Enrolled in a Cardiac Rehabilitation Program: A Randomized Crossover Trial

TypeinterventionalSponsorUniversidad de Santiago de ChileRan2026 to 2027Enrolled28ConditionsHeart Failure, Exercise Tolerance (Measured in Minutes), Cardiac RehabilitationArmsHigh-Flow Nasal Cannula (HFNC)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat?European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Tien-Pei FangDepartment of Respiratory Therapy, Chiayi Chang Gung Memorial Hospital, Chiayi.
Yen-Huey ChenDepartment of Respiratory Therapy, Chang Gung Technical University, Chiayi.
Hsiu-Feng HsiaoDepartment of Respiratory Therapy, Chang Gung University, Taoyuan.
Hsiu-Ying ChoDepartment of Respiratory Therapy, Chang Gung University, Taoyuan.
Ying-Huang TsaiDepartment of Respiratory Therapy, Chang Gung University, Taoyuan.
Chung-Chi HuangDepartment of Respiratory Therapy, Chang Gung University, Taoyuan.
Meng-Jer HsiehDepartment of Respiratory Therapy, Chang Gung University, Taoyuan.
Huang-Pin WuDepartment of Pulmonary and Critical Care Medicine, Keelung Chang Gung Memorial Hospital, Keelung.
Hui-Ling LinDepartment of Respiratory Therapy, Chiayi Chang Gung Memorial Hospital, Chiayi.
Chang Gung University · TWChiayi Chang Gung Memorial Hospital · TWRespiratory Clinical Trials · AUKeelung Chang Gung Memorial Hospital · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise training for patients with chronic obstructive pulmonary disease (COPD) improves their endurance and oxygenation. Supplemental oxygen delivered by high flow nasal cannula (HFNC) reportedly improves the clinical outcomes during high-intensity exercise. However, the physical benefits of the provision of supplemental oxygen with HFNC for the improvement of exercise performance have not been fully investigated. This randomized trial aimed to evaluate the effect of HFNC on the hemodynamic status and peripheral muscle microcirculation during exercise training.

methodsIn this multicenter, randomized controlled parallel two-group study, 32 patients with moderate to severe COPD were randomly assigned into the nasal cannula (NC) group (n=15) with a flow rate of 2-3 L/min or the HFNC group (n=17) with a flow rate of 45 L/min for twelve 40 min exercise training sessions.

resultsThe mean cardiac index (CI) and stroke volume (SV) of the NC group in the first session were significantly lower than those of the HFNC group (3.68±0.76

conclusionsHFNC, with a lower oxygen concentration than that used with a traditional NC, yielded lower deoxygenated hemoglobin levels after 12 suboptimal exercise training sessions. In contrast, the higher oxygen concentration delivered by NC reduced SVR. The COPD assessment score improved on exercise training, regardless of the supplemental oxygen delivery method.

Indexed as

exercise traininghemodynamicsHigh-flow nasal cannula oxygen therapymuscle perfusionpulmonary rehabilitation (PR)

Identifiers

PMID32355724
PMCPMC7186666
OpenAlexW3011384867

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.