Evidence map›Paper›PMID 32355646›Full record

ArticleQuantitative imaging in medicine and surgery2020

Evaluation of multi-shell diffusion MRI acquisition strategy on quantitative analysis using multi-compartment models.

Chun-Xia Li, Sudeep Patel, Xiaodong Zhang

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06606925 (Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06606925 nacompletednot on this mapstarted 2023, after this paper: background citation

Determining Which Regions of the Brain Are Active During Flight Simulation at Separate Timepoints During Training

TypeinterventionalSponsorThe Geneva FoundationRan2023 to 2026Enrolled35ConditionsCognitive PerformanceArmsfMRI with virtual reality flight simulator
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  7. Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging.International journal of environmental research and public health · 2023
    Review
  8. Article
  9. Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chun-Xia LiYerkes Imaging Center, Emory University, Atlanta, GA, USA.
Sudeep PatelYerkes Imaging Center, Emory University, Atlanta, GA, USA.
Xiaodong ZhangYerkes Imaging Center, Emory University, Atlanta, GA, USA.
Imaging Center · USEmory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
NIH HHS P51 OD011132
6 · The paper itself

Abstract

backgroundMulti-compartment diffusion models such as Neurite Orientation Dispersion and Density Imaging (NODDI) have been increasingly used for diffusion MRI (dMRI) data processing in biomedical research. However, those models usually require multiple HARDI shells that may increase scanning duration substantially, and their application can be hindered in uncooperative patients (like infants) accordingly. Also, it is highly expected that the same dataset can be explored with multiple diffusion models for retrieving complementary information.

methodsMultiple gradient-encoding schemes which consisted of 4-6 shells, moderate b-values (bmax =1,500 or 2,000 s/mm

resultsThe maps of orientation dispersion index (ODI) and CSF were consistent across the 4-6 shell sampling schemes. However, the corresponding intra-cellular volume fraction (ICVF) maps showed reduced pixel counts [1,100±98 (80 directions)

conclusionsThe present study reports a fast multi-shell dMRI data acquisition and processing strategy which allows for obtaining complementary information about microstructural alteration and inflammation from a single dMRI data set with both NODDI and DBSI models. The proposed approach may be particularly useful for characterizing the neurodegenerative disorders in uncooperative patients like children or acute stroke patients in which brain injury is associated with inflammation.

Indexed as

diffusion basic spectrum imaging (DBSI)diffusion tensor imaging (DTI)fast imaging protocolNeurite Orientation Dispersion and Density Imaging (NODDI)non-human primatepediatric

Identifiers

PMID32355646
PMCPMC7188617
OpenAlexW3016041098

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.