Evidence map›Paper›PMID 32355645›Full record

ArticleQuantitative imaging in medicine and surgery2020

Predicting clinically significant prostate cancer from quantitative image features including compressed sensing radial MRI of prostate perfusion using machine learning: comparison with PI-RADS v2 assessment scores.

David Jean Winkel, Hanns-Christian Breit, Bibo Shi, Daniel T Boll, Hans-Helge Seifert, Christian Wetterauer

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Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

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19citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

David Jean WinkelDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Hanns-Christian BreitDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Bibo ShiSiemens Medical Imaging Technologies, Princeton, NJ, USA.
Daniel T BollDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Hans-Helge SeifertDepartment of Urology, University Hospital Basel, Basel, Switzerland.
Christian WetterauerDepartment of Urology, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate if supervised machine learning (ML) classifiers would be able to predict clinically significant cancer (sPC) from a set of quantitative image-features and to compare these results with established PI-RADS v2 assessment scores.

methodsWe retrospectively included 201, histopathologically-proven, peripheral zone (PZ) prostate cancer lesions. Gleason scores ≤3+3 were considered as clinically insignificant (inPC) and Gleason scores ≥3+4 as sPC and were encoded in a binary fashion, serving as ground-truth. MRI was performed at 3T with high spatiotemporal resolution DCE using Golden-angle RAdial SParse (GRASP) MRI. Perfusion maps (Ktrans, Kep, Ve), apparent diffusion coefficient (ADC), and absolute T2-signal intensities (SI) were determined in all lesions and served as input parameters for four supervised ML models: Gradient Boosting Machines (GBM), Neural Networks (NNet), Random Forest (RF) and Support Vector Machines (SVM). ML results and PI-RADS scores were compared with the ground-truth. Next ROC-curves and AUC values were calculated.

resultsAll ML models outperformed PI-RADS v2 assessment scores in the prediction of sPC (RF, GBM, NNet and SVM

conclusionsUsing quantitative imaging parameters as input, supervised ML models outperformed PI-RADS v2 assessment scores in the prediction of sPC. These results indicate that quantitative imagining parameters contain relevant information for the prediction of sPC from image features.

Indexed as

magnetic resonance imaging (MRI)Prostatic neoplasmssupervised machine learning

Identifiers

PMID32355645
PMCPMC7188610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.