ArticleJournal of biological engineering2020
Acute mechanical stress in primary porcine RPE cells induces angiogenic factor expression and in vitro angiogenesis.
Article in Journal of biological engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway.Bone & joint research · 2026Article
- Polarimetric entropy mapping of retinal pigment epithelium in full-thickness macular hole by polarization-sensitive OCT.BMC ophthalmology · 2026Article
- Photodegradable Hydrogels for On-Demand Modeling of Age-Related Spatiotemporal ECM Deformation.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Changes in ApoE and TIMP-1 expression correlate with outer blood-retinal barrier disruption in an in vitro model of retinal aging.GeroScience · 2026Article
- Associations between mechanical stress and epigenetic modifications in outer retinal layer remodeling in high myopia.Frontiers in medicine · 2026Review
- Mechanobiological modulation: physiological pressure preconditioning boosts the paracrine-driven lymphangiogenic capacity of bone marrow mesenchymal stem cells.Frontiers in physiology · 2026Article
- Extracellular matrix stiffness modulates angiogenic properties of the retinal pigment epithelium.Scientific reports · 2025Article
- Role of Oxidative Stress and Inflammation in Age Related Macular Degeneration: Insights into the Retinal Pigment Epithelium (RPE).International journal of molecular sciences · 2025Review
- Key Claudins at the Blood-Retina Barriers.Advances in experimental medicine and biology · 2025Review
- Applying low levels of strain to model nascent phenomenon of retinal pathologies.Lab on a chip · 2024Article
- HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells.Disease models & mechanisms · 2024Article
- Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative Disorders Related?Pharmaceuticals (Basel, Switzerland) · 2023Article
- The impact of early RPE cell junction loss on VEGF, Ang-2, and TIMP secretion in vitro.Molecular vision · 2023Article
- Research progress of exosomes in pathogenesis, diagnosis, and treatment of ocular diseases.Frontiers in bioengineering and biotechnology · 2023Review
- Role of Herbal Extracts of Catechu fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography.Medicina (Kaunas, Lithuania) · 2020Article
- From stress to sight: The role of mechanical forces in the retinal diseases.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChoroidal neovascularization (CNV) is a major cause of blindness in patients with age-related macular degeneration. CNV is characterized by new blood vessel growth and subretinal fluid accumulation, which results in mechanical pressure on retinal pigment epithelial (RPE) cells. The overexpression of RPE-derived angiogenic factors plays an important role in inducing CNV. In this work, we investigated the effect of mechanical stress on the expression of angiogenic factors in porcine RPE cells and determined the impact of conditioned medium on in-vitro angiogenesis.
resultsThe goal of this study was to determine whether low levels of acute mechanical stress during early CNV can induce the expression of angiogenic factors in RPE cells and accelerate angiogenesis. Using a novel device, acute mechanical stress was applied to primary porcine RPE cells and the resulting changes in the expression of major angiogenic factors, VEGF, ANG2, HIF-1α, IL6, IL8 and TNF
conclusionsIn conclusion, we showed that acute mechanical stress induces the expression of major angiogenic and EMT factors and promotes in vitro angiogenesis, suggesting that mechanical stress plays a role in promoting aberrant angiogenesis in AMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.