ArticleTropical medicine and health2020
Effect of tuberculosis infection on mortality of HIV-infected patients in Northern Tanzania.
Article in Tropical medicine and health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: a systematic review and meta-analysis.International health · 2026Pooled it
- Determinants of HIV related mortality in African children on antiretroviral therapy: clinical and immunological insights from a systematic review and meta-analysis.AIDS research and therapy · 2025Pooled it
- Meta-analysis of TB & HIV co-infection mortality rate in sub-Saharan African children, youth, and adolescents.Italian journal of pediatrics · 2025Pooled it
- Impact of HIV coinfection on tuberculosis treatment outcomes in Ethiopia: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Burden of mortality and its predictors among TB-HIV co-infected patients in Ethiopia: Systematic review and meta-analysis.PloS one · 2024Pooled it
- Pharmacodynamic biomarkers for quantifying the mycobacterial effect of high doses of rifampin in patients with rifampin-susceptible pulmonary tuberculosis.International journal of mycobacteriologyTrial
- Early immune dysregulation iniScience · 2026Article
- Article
- Parametric Bayesian modelling of tuberculosis mortality determinants and facility level heterogeneity effect using Gamma and Gaussian shared frailty techniques.BMC infectious diseases · 2026Article
- Predictors of tuberculosis mortality among patients on treatment: A retrospective cohort study at a rural general hospital in Zambia.PloS one · 2026Article
- Prevalence, Risk Factors and Residential Variation Among HIV/TB Coinfected Mortality in Fenote Selam Hospital, Amhara Region: A Retrospective Study.Health science reports · 2025Article
- Provider fidelity in tuberculosis screening practices among adolescents and adults living with HIV in public health facilities in Tanzania: a cross-sectional evaluation.Frontiers in public health · 2025Article
- Active Tuberculosis Is Associated with Depletion of HIV-Specific CD4 and CD8 T Cells in People with HIV.AIDS research and human retroviruses · 2024Article
- Article
- Review
- Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019.Diagnostics (Basel, Switzerland) · 2023Article
- Landscape of TB Infection and Prevention among People Living with HIV.Pathogens (Basel, Switzerland) · 2022Review
- Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.Scientific reports · 2022Article
- Different diets and their effect on tuberculosis prevention in HIV patients.Journal of family medicine and primary care · 2022Article
- Increased Mortality in HIV Infected Individuals with Tuberculosis: A Retrospective Cohort Study, Addis Ababa, Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTB and HIV are public health problems, which have a synergistic effect to each other. Despite the decreasing burden of these two diseases they still make a significant contribution to mortality. Tanzania is among the 30 high TB and HIV burden countries.
methodsRoutine data over 6 years from people living with HIV (PLHIV) attending health facilities in three regions of Northern Tanzania were analyzed, showing mortality trends from 2012 to 2017 for HIV and HIV/TB subpopulations. Poisson regression with frailty model adjusting for clustering at health facility level was used to analyze the data to determine mortality rate ratios (RR) and 95% confidence intervals (95%CI).
resultsAmong all PLHIV the overall mortality rate was 28.4 (95% CI 27.6-29.2) deaths per 1000 person-years. For PLHIV with no evidence of TB the mortality rates was 26.2 (95% CI 25.4-27.0) per 1000 person-years, and for those with HIV/TB co-infection 57.8 (95% CI 55.6-62.3) per 1000 person-years. After adjusting for age, sex, residence, WHO stage, and bodyweight, PLHIV with TB co-infection had 40% higher mortality than those without TB (RR 1.4; 95% CI 1.24-1.67).
conclusionsOver the 6-year period mortality rates for HIV/TB patients were consistently higher than for PLHIV who have no TB. More efforts should be directed into improving nutritional status among HIV patients, as it has destructive interaction with TB for mortality. This will improve patients' body weight and CD4 counts which are protective against mortality. Among PLHIV attention should be given to those who are in WHO HIV stage 3 or 4 and having TB co-infection.
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