Prevention of respiratory infections with alpha- and gamma-herpesviruses in weanling foals by using a modified live intra-nasal equine influenza vaccine.

Rebeca Salco, Jeanne Bowers, Virginia Hernandez, Samantha Barnum, Nicola Pusterla

Open access · greenAbstract read

In one paragraph

Article in The Canadian veterinary journal = La revue veterinaire canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 59% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

A Live-Attenuated Equine Influenza Vaccine Stimulates Innate Immunity in Equine Respiratory Epithelial Cell Cultures That Could Provide Protection From Equine Herpesvirus 1.Frontiers in veterinary science · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebeca SalcoDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California, USA (Pusterla, Barnum); Harris Farms Horse Division, 27366 West Oakland Avenue, Coalinga, California, USA (Salco, Bowers, Hernandez).

Jeanne BowersDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California, USA (Pusterla, Barnum); Harris Farms Horse Division, 27366 West Oakland Avenue, Coalinga, California, USA (Salco, Bowers, Hernandez).

Virginia HernandezDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California, USA (Pusterla, Barnum); Harris Farms Horse Division, 27366 West Oakland Avenue, Coalinga, California, USA (Salco, Bowers, Hernandez).

Samantha BarnumDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California, USA (Pusterla, Barnum); Harris Farms Horse Division, 27366 West Oakland Avenue, Coalinga, California, USA (Salco, Bowers, Hernandez).

Nicola PusterlaDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, California, USA (Pusterla, Barnum); Harris Farms Horse Division, 27366 West Oakland Avenue, Coalinga, California, USA (Salco, Bowers, Hernandez).

University of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to determine if the administration of a modified live equine influenza virus vaccine (FluAvert) to foals would positively impact their health and reduce colonization of their upper airways with equine herpesviruses (EHV) during the weaning period. A single dose of FluAvert was given to 20 healthy foals 7 days prior to being weaned; 20 healthy foals served as unvaccinated controls. Nasal secretions and blood were collected before vaccination, the day of weaning, and weekly thereafter for 3 weeks. Nasal secretions were tested by quantitative polymerase chain reaction (qPCR) for EHV-1, -2, -4 and -5. Whole blood was analyzed for a complete blood cell count and fibrinogen concentration. Physical assessments were made daily. The use of FluAvert was associated with a better clinical outcome. However, the equine influenza virus (EIV) vaccine did not influence selected hematological parameters and kinetics of herpesviruses. The clinical benefit observed in vaccinates may explain the perception that the EIV vaccine induces cross-protection against respiratory agents.

Indexed as

Influenza VaccinesAnimalsAntibodies, ViralHerpesviridae InfectionsHerpesvirus 1, EquidHorse DiseasesHorsesRespiratory Tract InfectionsAntibodies, ViralInfluenza Vaccines

Identifiers

PMID32355351

PMCPMC7155874

OpenAlexW3020828925

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.