ArticleScientific reports2020
Genetic basis for virulence differences of various Cryptosporidium parvum carcinogenic isolates.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Pooled it
- Molecular and genetic characterization of Kudoa septempunctata from foodborne outbreaks in the Republic of Korea, 2016-2024: a retrospective public-health surveillance investigation.Osong public health and research perspectives · 2026Article
- Article
- Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite.Cell host & microbe · 2025Article
- Deciphering Host-Pathogen Interactions: Role ofPathogens (Basel, Switzerland) · 2025Review
- Sequence introgression from exogenous lineages underlies genomic and biological differences among Cryptosporidium parvum IOWA lines.Water research · 2024Article
- Article
- Differences in virulence and oocyst shedding profiles in lambs experimentally infected with different isolates ofCurrent research in parasitology & vector-borne diseases · 2023Article
- A novel, stain-free, natural auto-fluorescent signal, Sig M, identified from cytometric and transcriptomic analysis of infectivity ofFrontiers in cellular and infection microbiology · 2023Article
- High infectivity and unique genomic sequence characteristics of Cryptosporidium parvum in China.PLoS neglected tropical diseases · 2022Article
- IsFood and waterborne parasitology · 2022Article
- Genotypic variation in an ecologically important parasite is associated with host species, lake and spore size.Parasitology · 2021Article
- Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptosporidium parvum is known to cause life-threatening diarrhea in immunocompromised hosts and was also reported to be capable of inducing digestive adenocarcinoma in a rodent model. Interestingly, three carcinogenic isolates of C. parvum, called DID, TUM1 and CHR, obtained from fecal samples of naturally infected animals or humans, showed higher virulence than the commercially available C. parvum IOWA isolate in our animal model in terms of clinical manifestations, mortality rate and time of onset of neoplastic lesions. In order to discover the potential genetic basis of the differential virulence observed between C. parvum isolates and to contribute to the understanding of Cryptosporidium virulence, entire genomes of the isolates DID, TUM1 and CHR were sequenced then compared to the C. parvum IOWA reference genome. 125 common SNVs corresponding to 90 CDSs were found in the C. parvum genome that could explain this differential virulence. In particular variants in several membrane and secreted proteins were identified. Besides the genes already known to be involved in parasite virulence, this study identified potential new virulence factors whose functional characterization can be achieved through CRISPR/Cas9 technology applied to this parasite.
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