ReviewNature reviews. Disease primers2020
Vulvodynia.
Review in Nature reviews. Disease primers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138171 (Psychological Layers of Nociplastic Pain), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychological Layers of Nociplastic Pain: Cluster Analysis of The Role of Personality Traits, Defence Mechanisms, Central Sensitization, and Childhood Traumatic Experiences in Patients With Chronic Migraine, Fibromyalgia, and Vulvodynia
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Beyond the placebo effect: a systematic review and a network meta-analysis of treatment strategies for vulvodynia.BMC women's health · 2026Pooled it
- Obstetric outcomes in women with vulvodynia and vaginismus: a systematic review.Archives of gynecology and obstetrics · 2025Pooled it
- Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.International journal of molecular sciences · 2024Pooled it
- "Time is on my side". Disease trajectory of vulvodynia: a systematic review with a narrative synthesis.Archives of gynecology and obstetrics · 2024Pooled it
- Health economic evaluation of a randomized controlled trial (EMBLA study), an internet-based treatment for provoked vulvodynia.Scientific reports · 2023Trial
- Pelvic floor examination in vulvodynia: VAMP protocol validation in correlation with central sensitization.Women's health (London, England)Trial
- Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations.Cell reports. Medicine · 2026Review
- Tampon test measurement properties in women with provoked vestibulodynia: baseline data from a pragmatic randomized clinical trial.Sexual medicine · 2026Article
- Review
- Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial.AJOG global reports · 2026Article
- Lichen sclerosus. Part 1. Guideline of the DGG, DGGG, OEGGG and SGGG (S3-Level, AWMF Registry No. 013-105, July 2025.Geburtshilfe und Frauenheilkunde · 2026Article
- Comorbid Conditions of Ehlers-Danlos Syndromes and Vulvodynia: A Latent Class Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Sexual Distress Scale: Translation, Psychometric Validation, and Reference Values for Cisgender Women and Men in a Representative Population-based Sample in Germany.Geburtshilfe und Frauenheilkunde · 2026Article
- Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.Journal of clinical medicine · 2026Review
- Narratives on Sexuality in Vulvodynia and Endometriosis: A Qualitative Study on Italian Couples.Archives of sexual behavior · 2026Article
- Exposure-based Interventions for Chronic Pain and Bodily Symptoms: A Special Interest Meeting Report.Behaviour research and therapy · 2026Article
- Idiopathic vulvodynia - a psychosomatic disease? A cross-sectional single-center study.BMC women's health · 2026Article
- Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia.Molecular brain · 2026Article
- Vulvodynia: still a dramatically neglected condition. A position statement on pathogenetic mechanisms from the Italian Society of Andrology and Sexual Medicine (SIAMS).Journal of endocrinological investigation · 2026Review
- Sensory Processing Sensitivity and Maladaptive Personality Traits in Chronic Pain Conditions: A Network Analysis Perspective.Pain research & management · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Vulvodynia is a condition that occurs in 8-10% of women of all ages and is characterized by pain at the vulva that is present during sexual and/or non-sexual situations. Diagnosis is established through careful medical history and pelvic examination, including the cotton-swab test. The onset and maintenance of vulvodynia involves a complex interplay of peripheral and central pain mechanisms, pelvic floor muscle and autonomic dysfunction, anxiety, depression and childhood maltreatment as well as cognitive-affective, behavioural and interpersonal factors. Given the absence of empirically supported treatment guidelines, a stepwise approach of pelvic floor physical therapy and cognitive behavioural therapy as well as medical management is suggested, with surgery as the last option. Vulvodynia has a negative effect on the quality of life of women and their partners, and imposes a profound personal and societal economic burden. In addition, women with vulvodynia are more likely to report other chronic pain conditions, which further alters their quality of life. Future efforts should aim to increase girls', women's and healthcare professionals' education and awareness of vulvodynia, phenotype different subgroups of women based on biopsychosocial characteristics among more diverse samples, conduct longitudinal studies and improve clinical trial designs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.