ArticleScientific reports2020
Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 259 citations in OpenAlex.
- Structure-Biofunction Relationships in Nanoparticle-Reinforced PVA/Alginate Hydrogels for Infection-Controlled Tissue-Contact Applications.ACS omega · 2026Article
- Biopolymer-Based Hydrogels for Wound Healing: Advances in Cellulose, Chitosan, Alginate, and Hyaluronic Acid from Design to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Alginate-PVA interpenetrating network nanogels: a pH-responsive carrier for thermal stabilization and sustained release of phycocyanin.Food chemistry: X · 2026Article
- Freeze-Thaw-Induced Physically Cross-Linked Poly(Vinyl Alcohol)/Alginate Hydrogels Incorporating Silver-Doped Zinc Oxide and Clove Oil.Biopolymers · 2026Article
- Interpenetrating gelatin/sodium alginate hydrogel with controlled PRP lysate delivery for accelerating diabetic wound healing with reduced scarring.RSC advances · 2026Article
- Self-healing PVA/PVP micelle-hydrogel composite system for potential phenytoin repositioning in wound healing.Journal of biological engineering · 2025Article
- Article
- Alginate/PVA Hydrogel Incorporating HA-Liposomes and Aronia-Derived Silver Nanoparticles for Advanced Wound Management.International journal of molecular sciences · 2025Article
- Evaluation of alginate/poly(vinyl alcohol)/BaSORSC advances · 2025Article
- Sustainable Durian Rind Carboxymethyl Cellulose/Poly(vinyl) Alcohol Hydrogels Synthesis for Enhancing Crosslinking and Release Kinetics Efficiency.Gels (Basel, Switzerland) · 2025Article
- Biological Models for Evaluating Hydrogel-Based Formulations in Wound Healing.Gels (Basel, Switzerland) · 2025Review
- Immunomodulatory Natural Products in Cancer Organoid-Immune Co-Cultures: Bridging the Research Gap for Precision Immunotherapy.International journal of molecular sciences · 2025Review
- Investigating How All-Trans Retinoic Acid Polycaprolactone (atRA-PCL) Microparticles Alter the Material Properties of 3D Printed Fibrin Constructs.Macromolecular bioscience · 2025Article
- Photoactivated Curcumin-Loaded Lipid Nanoparticles in Hydrogel: A Cutting-Edge Intracanal Medicament for Advanced Endodontic Therapy.Gels (Basel, Switzerland) · 2025Article
- Integrating melt electrowriting (MEW) PCL scaffolds with fibroblast-laden hydrogel toward vascularized skin tissue engineering.Materials today. Bio · 2025Article
- Development of a Chitosan-Silver Nanocomposite/β-1,3-Glucan/Hyaluronic Acid Composite as an Antimicrobial System for Wound Healing.Polymers · 2025Article
- Amine-Functionalized NiCoFeInternational journal of nanomedicine · 2025Article
- Preparation Methods of Hydrogel Microspheres and Recent Advances in Their Application for Treating Diabetic Wounds.International journal of nanomedicine · 2025Review
- Hybrid Hydrogel Supplemented with Algal Polysaccharide for Potential Use in Biomedical Applications.Gels (Basel, Switzerland) · 2024Article
- Cannabidiol-Loaded Lipid Nanoparticles Incorporated in Polyvinyl Alcohol and Sodium Alginate Hydrogel Scaffold for Enhancing Cell Migration and Accelerating Wound Healing.Gels (Basel, Switzerland) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, a hybrid microsphere/hydrogel system, consisting of polyvinyl alcohol (PVA)/sodium alginate (SA) hydrogel incorporating PCL microspheres is introduced as a skin scaffold to accelerate wound healing. The hydrogel substrate was developed using the freeze-thawing method, and the proportion of the involved polymers in its structure was optimized based on the in-vitro assessments. The bFGF-encapsulated PCL microspheres were also fabricated utilizing the double-emulsion solvent evaporation technique. The achieved freeze-dried hybrid system was then characterized by in-vitro and in-vivo experiments. The results obtained from the optimization of the hydrogel showed that increasing the concentration of SA resulted in a more porous structure, and higher swelling ability, elasticity and degradation rate, but decreased the maximum strength and elongation at break. The embedding of PCL microspheres into the optimized hydrogel structure provided sustained and burst-free release kinetics of bFGF. Besides, the addition of drug-loaded microspheres led to no significant change in the degradation mechanism of the hydrogel substrate; however, it reduced its mechanical strength. Furthermore, the MTT assay represented no cytotoxic effect for the hybrid system. The in-vivo studies on a burn-wound rat model, including the evaluation of the wound closure mechanism, and histological analyses indicated that the fabricated scaffold efficiently contributed to promoting cell-induced tissue regeneration and burn-wound healing.
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