Evidence map›Paper›PMID 32355240›Full record

ArticleScientific reports2020

Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice.

Hanjay Wang, Ross Bennett-Kennett, Michael J Paulsen, Camille E Hironaka, Akshara D Thakore, Justin M Farry, Anahita Eskandari, Haley J Lucian, Hye Sook Shin, Matthew A Wu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Biomechanical Analysis of the Ross Procedure in an Ex Vivo Left Heart Simulator.World journal for pediatric & congenital heart surgery · 2022
    Article
  3. Article
  4. Article
  5. Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration.Frontiers in cell and developmental biology · 2021
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Ross Bennett-KennettDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Camille E HironakaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Akshara D ThakoreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Justin M FarryDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Anahita EskandariDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Haley J LucianDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hye Sook ShinDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Matthew A WuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Annabel M Imbrie-MooreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Lyndsay M StapletonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Yuanjia ZhuDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Reinhold H DauskardtDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.
Stanford University · USCardiovascular Institute of the South · US

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
NHLBI NIH HHS R01 HL089315
6 · The paper itself

Abstract

Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains unknown. We hypothesized that neonatal heart regeneration preserves native left ventricular (LV) biomechanical properties after MI. C57BL/6J mice underwent sham surgery or left anterior descending coronary artery ligation at age P1 or P7. Echocardiography performed 4 weeks post-MI showed that P1 MI and sham mice (n = 22, each) had similar LV wall thickness, diameter, and ejection fraction (59.6% vs 60.7%, p = 0.6514). Compared to P7 shams (n = 20), P7 MI mice (n = 20) had significant LV wall thinning, chamber enlargement, and depressed ejection fraction (32.6% vs 61.8%, p < 0.0001). Afterward, the LV was explanted and pressurized ex vivo, and the multiaxial lenticular stress-strain relationship was tracked. While LV tissue modulus for P1 MI and sham mice were similar (341.9 kPa vs 363.4 kPa, p = 0.6140), the modulus for P7 MI mice was significantly greater than that for P7 shams (691.6 kPa vs 429.2 kPa, p = 0.0194). We conclude that, in neonatal mice, regenerated LV muscle has similar biomechanical properties as native LV myocardium.

Indexed as

RegenerationAnimalsAnimals, NewbornBiomechanical PhenomenaCell ProliferationCollagenEchocardiographyFemaleHeartHeart VentriclesMiceMice, Inbred C57BLMyocardial InfarctionMyocardiumMyocytes, CardiacStress, MechanicalCollagen

Identifiers

PMID32355240
PMCPMC7193551
OpenAlexW3021099842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.