ArticleNature communications2020
Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Structural basis of liver de-targeting and neuronal tropism of CNS-targeted AAV capsids.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Integrated theranostic nanoplatform empowers precision cancer care via radionuclide-labeled NIR-II aggregation-induced emission luminogens.Nature communications · 2026Article
- Where did my vector go and how well did it function? PET biodistribution studies of viral gene therapy vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Exploring AAV-Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Recent developments in translational imaging of in vivo gene therapy outcomes.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Adeno-associated viruses escort nanomaterials to specific cells and tissues.bioRxiv : the preprint server for biology · 2025Article
- Brain-Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- PET imaging of AAV9 and AAVBR1 trafficking in normal mice.Scientific reports · 2025Article
- A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice.Molecular therapy. Methods & clinical development · 2024Article
- Human cell surface-AAV interactomes identify LRP6 as blood-brain barrier transcytosis receptor and immune cytokine IL3 as AAV9 binder.Nature communications · 2024Article
- Chemical approaches to probe and engineer AAV vectors.Nanoscale · 2024Review
- Multifunctional Fluoropolymer-Engineered Magnetic Nanoparticles to Facilitate Blood-Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Engineered compact pan-neuronal promoter from Alphaherpesvirus LAP2 enhances target gene expression in the mouse brain and reduces tropism in the liver.Gene therapy · 2024Article
- Redirecting AAV vectors to extrahepatic tissues.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Review
- Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression.Nature methods · 2023Article
- PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brain.Theranostics · 2023Article
- Multimodal imaging of capsid and cargo reveals differential brain targeting and liver detargeting of systemically-administered AAVs.Biomaterials · 2022Article
- The δ subunit of FNature communications · 2021Article
- Translational PET applications for brain circuit mapping with transgenic neuromodulation tools.Pharmacology, biochemistry, and behavior · 2021Review
- Viral tools for neuroscience.Nature reviews. Neuroscience · 2020Review
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 1 country.
Jai Woong SeoMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2732-7498
Elizabeth S InghamDepartment of Biomedical Engineering, University of California, Davis, CA, USA.
Lisa MahakianDepartment of Biomedical Engineering, University of California, Davis, CA, USA.
Spencer TumbaleMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Bo WuMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Sadaf AghevlianMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Shahin ShamsDepartment of Biomedical Engineering, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9122-0364
Mo BaikoghliDepartment of Molecular and Cellular Biology, University of California, Davis, CA, USA.
Poorva JainMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Xiaozhe DingDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-0267-0791
Nick GoedenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Tatyana DobrevaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Nicholas C FlytzanisDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0002-7921-9392
Michael ChavezDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Kratika SinghalStanford University Mass Spectrometry, Stanford, CA, USA.
Ryan LeibStanford University Mass Spectrometry, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8129-1916
Michelle L JamesMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
David J SegalGenome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-8962-3105
R Holland ChengDepartment of Molecular and Cellular Biology, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-2068-7271
Eduardo A SilvaDepartment of Biomedical Engineering, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0003-3173-7622
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-5868-348X
Katherine W FerraraMolecular Imaging Program at Stanford (MIPS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA. kwferrar@stanford.edu.ORCID http://orcid.org/0000-0002-4976-9107
Stanford University · USUniversity of California, Davis · USCalifornia Institute of Technology · USStanford Medicine · US
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9MTranslational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4MIn vivo PET imaging of novel engineered AAVs informs capsid design in Alzheimer's DiseaseR01EB028646 · NIBIB · STANFORD UNIVERSITY · PI FERRARA, KATHERINE W · 2019 to 2022
$3.8MThe Impact of FUS-Mediated Brain Cancer Therapy on BBB Transport, Cytokines, and Immunocyte TraffickingR01CA227687 · NCI · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2018 to 2022
$3.1MCell-specific nanocarrier with endocytic and endosomolytic activities for therapeutic genome editingUG3TR002866 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND, LAM, KIT S · 2019 to 2021
$2.3MNCATS NIH HHS UG3 TR002866
Abstract
Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY6A receptor on brain endothelial cells. Here, we create a non-invasive positron emission tomography (PET) methodology to track viruses. To provide the sensitivity required to track AAVs injected at picomolar levels, a unique multichelator construct labeled with a positron emitter (Cu-64, t
Indexed as
Positron-Emission TomographyAnimalsBrainCapsidChelating AgentsCopper RadioisotopesDependovirusFemaleGenetic VectorsHEK293 CellsHumansMiceMice, Inbred BALB CMice, Inbred C57BLTransduction, GeneticChelating AgentsCopper-64Copper Radioisotopes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.